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Drug-Induced Insomnia and Excessive Sleepiness

  • Ann Van Gastel
    Correspondence
    Drie Eikenstraat 655, 2650 Edegem, Antwerp, Belgium.
    Affiliations
    Multidisciplinary Sleep Disorders Centre and University Department of Psychiatry, Antwerp University Hospital, Drie Eikenstraat 655, 2650 Edegem, Antwerp, Belgium

    Faculty of Medicine and Health Sciences, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp (UA), Campus Drie Eiken, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium
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Published:September 07, 2022DOI:https://doi.org/10.1016/j.jsmc.2022.06.011

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      References

        • Monti J.M.
        The effect of second-generation antipsychotic drugs on sleep parameters in patients with unipolar or bipolar disorder.
        Sleep Med. 2016; 23: 89-96
        • Monti J.M.
        The neurotransmitters of sleep and wake, a physiological reviews series.
        Sleep Med Rev. 2013; 17: 313-315
        • Luppi P.H.
        • Clement O.
        • Fort P.
        Paradoxical (REM) sleep genesis by the brainstem is under hypothalamic control.
        Curr Opin Neurobiol. 2013; 23: 1-7
        • Sateia M.C.
        • Buysse D.J.
        Insomnia diagnosis and treatment.
        1st edition. Informa healthcare, London2010
        • Wilson S.
        • Argyropoulos S.
        Antidepressants and sleep: a qualitative review of the literature.
        Drugs. 2005; 65: 927-947
        • Wichniak A.
        • Wierzbicka A.
        • Walecka M.
        • et al.
        Effects of antidepressants on sleep.
        Curr Psychiatry Rep. 2017; 19: 63
        • Doghramji K.
        • Jangro W.C.
        Adverse effects of psychotropic medications on sleep.
        Psychiatr Clin North Am. 2016; 39: 487-502
        • Roth T.
        • Rogowski R.
        • Hull S.
        • et al.
        Efficacy and safety of doxepin 1 mg, 3 mg, and 6 mg in adults with primary insomnia.
        Sleep. 2007; 30: 1555-1561
        • Alberti S.
        • Chiesa A.
        • Andrisano C.
        • et al.
        Insomnia and somnolence associated with second-generation antidepressants during the treatment of major depres sion: a meta-analysis.
        J Clin Psychopharmacol. 2015; 35: 296-303
        • Nofzinger E.A.
        • Reynolds 3rd, C.F.
        • Thase M.E.
        • et al.
        REM sleep enhancement by bupropion in depressed men.
        Am J Psychiatry. 1995; 152: 274-276
        • Holshoe J.M.
        Antidepressants and sleep: a review.
        Perspect Psychiatr Care. 2009; 45: 191-197
        • Haddad P.M.
        Antidepressant discontinuation syndromes.
        Drug Saf. 2001; 24: 183-197
        • Sadock B.J.
        • Sadock V.A.
        • Ruiz P.
        Kaplan and Sadock’s synopsis of psychiatry. Behavioral sciences/clinical psychiatry.
        11th edition. Wolters Kluwer, Philadelphia2015
        • Krystal A.D.
        • Goforth H.W.
        • Roth T.
        Effects of antipsychotic medications on sleep in schizophrenia.
        Int Clin Psychopharmacol. 2008; 23: 150-160
        • Gao K.
        • Mackle M.
        • Cazorla P.
        • et al.
        Comparison of somnolence associated with asenapine, olanzapine, risperidone, and haloperidol relative to placebo in patients with schizophrenia or bipolar disorder.
        Neu-ropsychiatr Dis Treat. 2013; 9: 1145-1157
        • Kluge M.
        • Himmerich H.
        • Wehmeier P.M.
        • et al.
        Sleep propensity at daytime as assessed by Multiple Sleep Latency Tests (MSLT) in patients with schizophrenia increases with clozapine and olanzapine.
        Schizophr Res. 2012; 135: 123-127
        • Loebel A.D.
        • Siu C.O.
        • Cucchiaro J.B.
        • et al.
        Daytime sleepiness associated with lurasidone and quetiapine XR: results from a randomized double-blind, placebo-controlled trial in patients with schizophrenia.
        CNS Spectr. 2014; 19: 197-205
        • Luthringer R.
        • Staner L.
        • Noel N.
        • et al.
        A double-blind, placebo-controlled, randomized study evaluating the effect of paliperidone extended-release tablets on sleep architecture in patients with schizophrenia.
        Int Clin Psychopharmacol. 2007; 22: 299-308
        • Ücok A.
        • Saka M.C.
        • Bilici M.
        Effects of paliperidone extended release on functioning level and symp-toms of patients with recent onset schizophrenia: an open-label, single-arm, flexible-dose, 12-months follow-up study.
        Nord J Psychiatry. 2015; 69: 426-432
        • Wiegand M.H.
        • Landry F.
        • Bruckner T.
        • et al.
        Quetiapine in primary insomnia: a pilot study.
        Psychopharmacology (Berl). 2008; 196: 337-338
        • Bohra M.H.
        • Kaushik C.
        • Temple D.
        • et al.
        Weighing the balance: how analgesics used in chronic pain influence sleep?.
        Br J Pain. 2014; 8: 107-118
        • Jain S.V.
        • Kothare S.V.
        Sleep and epilepsy.
        Semin Pediatr Neurol. 2015; 22: 86-92
        • Bazil C.W.
        Nocturnal seizures and the effects of anticonvulsants on sleep.
        Curr Neurol Neurosci Rep. 2008; 8: 149-154
        • Jain S.V.
        • Glauser T.A.
        Effects of epilepsy treatments on sleep architecture and daytime sleepiness: an evidence-based review of objective sleep metrics.
        Epilepsia. 2014; 55: 26-37
        • Schweitzer P.K.
        • Randazzo A.C.
        Drugs that disturb sleep and wakefulness.
        in: Kryger M.H. Roth T. Dement W.C. Principles and practice of sleep medicine. 6th edition. Elsevier, Philadelphia2017: 480-498
        • Vossler D.G.
        • Morris 3rd, G.L.
        • Harden C.L.
        • et al.
        Post marketing Antiepileptic Drug Survey (PADS) Group Study Investigators. Tiagabine in clinical practice: effects on seizure control and behavior.
        Epilepsy Behav. 2013; 28: 211-216
        • Sadler M.
        Lamotrigine associated with insomnia.
        Epilepsia. 1999; 40: 322-325
        • Schweitzer P.K.
        Excessive sleepiness due to medications and drugs.
        in: Thorpy M.J. Billiard M. Sleepiness: causes, consequences and treatment. Cambridge University Press, United Kingdom2011: 386-398
        • Leppik I.E.
        Zonisamide.
        Epilepsia. 1999; 40: S23-S29
        • Glauser T.A.
        Topiramate.
        Epilepsia. 1999; 40: S71-S80
        • Hetland A.
        • Carr D.B.
        Medications and impaired driving.
        Ann Pharmacother. 2014; 48: 494-506
        • Garcia-Borreguero D.
        • Kohnen R.
        • Silber M.H.
        • et al.
        The long-term treatment of restless legs syndrome/Willis-Ekbom disease: evidence-based guidelines and clinical consensus best practice guidance: a report from the International Restless Legs Syndrome Study Group.
        Sleep Med. 2013; 14: 675-684
        • Connolly B.S.
        • Lang A.E.
        Pharmacological treatment of Parkinson disease: a review.
        JAMA. 2014; 311: 1670-1683
        • Videnovic A.
        • Golombek D.
        Circadian and sleep disorders in Parkinson’s disease.
        Exp Neurol. 2013; 243: 45-56
        • Chahine L.M.
        • Amara A.W.
        • Videnovic A.
        A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015.
        Sleep Med Rev. 2017; 35: 33-50
        • Schug S.A.
        • Garrett W.R.
        • Gillespie G.
        Opioid and non- opioid analgesics.
        Best Pract Res Clin Anaesthesiol. 2003; 17: 91-110
        • Datta S.
        • Maclean R.R.
        Neurobiological mechanisms for the regulation of mammalian sleep-wake behavior: reinterpretation of historical evidence and inclusion of contemporary cellular and molecular evidence.
        Neurosci Biobehav Rev. 2007; 31: 775-824
        • Horne J.A.
        Aspirin and nonfebrile waking oral temperature in healthy men and women: links with SWS changes.
        Sleep. 1989; 12: 516-521
        • Murphy P.J.
        • Badia P.
        • Myers B.L.
        • et al.
        Nonsteroidal anti-inflammatory drugs affect normal sleep patterns in humans.
        Physiol Behav. 1994; 55: 1063-1066
        • Gengo F.
        Effects of ibuprofen on sleep quality as measured using polysomnography and subjective measures in healthy adults.
        Clin Ther. 2006; 28: 1820-1826
        • Horne J.A.
        • Percival J.E.
        • Traynor J.R.
        Aspirin and human sleep.
        Electroencephalogr Clin Neurophysiol. 1980; 49: 409-413
        • Lavie P.
        • Nahir M.
        • Lorber M.
        • et al.
        Nonsteroidal anti inflammatory drug therapy in rheumatoid arthritis patients. Lack of association between clinical improvement and effects on sleep.
        Arthritis Rheum. 1991; 34: 655-659
        • Lacovides S.
        • Avidon I.
        • Bentley A.
        • et al.
        Diclofenac potassium restores objective and subjective measures of sleep quality in women with primary dysmenorrhea.
        Sleep. 2009; 32: 1019-1026
        • Moore J.T.
        • Kelz M.B.
        Opiates, sleep, and pain: the adenosinergic link.
        Anesthesiology. 2009; 111: 1175-1176
        • Cronin A.J.
        • Keifer J.C.
        • Davies M.F.
        • et al.
        Postoperative sleep disturbance: influences of opioids and pain in humans.
        Sleep. 2001; 24: 39-44
        • Onen S.H.
        • Onen F.
        • Courpron P.
        • et al.
        How pain and analgesics disturb sleep.
        Clin J Pain. 2005; 21: 422-431
        • Nesbitt A.D.
        Headache, drugs and sleep.
        Cephalalgia. 2014; 34: 756-766
        • Dodick D.W.
        • Martin V.
        Triptans and CNS side-effects: pharmacokinetic and metabolic mechanisms.
        Cephalalgia. 2004; 24: 417-424
        • Goadsby P.J.
        • Dodick D.W.
        • Almas M.
        • et al.
        Treatment- emergent CNS symptoms following triptan therapy are part of the attack.
        Cephalalgia. 2007; 27: 254-262
        • Hu Y.
        • Sieck D.E.
        • Hsu W.H.
        Why are second- generation H1-antihistamines minimally sedating?.
        Eur J Pharmacol. 2015; 765: 100-106
        • Tashiro M.
        • Sakurada Y.
        • Iwabuchi K.
        • et al.
        Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography.
        J Clin Pharmacol. 2004; 44: 890-900
        • Yanai K.
        • Yoshikawa T.
        • Yanai A.
        • et al.
        The clinical pharmacology of non-sedating antihistamines.
        Phar Macol Ther. 2017; 178: 148-156
        • Pagel J.F.
        • Helfter P.
        Drug induced nightmares - an etiology based review.
        Hum Psychopharmacol. 2003; 18: 59-67
        • Arendt J.
        • Bojkowski C.
        • Franey C.
        • et al.
        Immuno- assay of 6-hydroxymelatonin sulfate in human plasma and urine: abolition of the urinary 24-hour rhythm with atenolol.
        J Clin Endocrinol Metab. 1985; 60: 1166-1173
        • Nathan P.J.
        • Maguire K.P.
        • Burrows G.D.
        • et al.
        The effect of atenolol, a beta1-adrenergic antagonist, on nocturnal plasma melatonin secretion: evidence for a dose-response relationship in humans.
        J Pineal Res. 1997; 23: 131-135
        • Stoschitzky K.
        • Sakotnik A.
        • Lercher P.
        • et al.
        Influence of beta-blockers on melatonin release.
        Eur J Clin Pharmacol. 1999; 55: 111-115
        • Scheer F.A.
        • Morris C.J.
        • Garcia J.I.
        • et al.
        Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: a randomized controlled trial.
        Sleep. 2012; 35: 1395-1402
        • Kosari S.
        • Naunton M.
        Sleep disturbances and nightmares in a patient treated with prazosin.
        J Clin Sleep Med. 2016; 12: 631-632
        • Kantola I.
        • Terént A.
        • Honkanen T.
        • et al.
        Efficacy and safety of spirapril, a new ace-inhibitor, in elderly hy pertensive patients.
        Eur J Clin Pharmacol. 1996; 50: 155-159
        • Gundersen T.
        • Wiklund I.
        • Swedberg K.
        • et al.
        Effects of 12 weeks of ramipril treatment on the quality of life in patients with moderate congestive heart failure: results of a placebo-controlled trial. Ramipril Study Group.
        Cardiovasc Drugs Ther. 1995; 9: 589-594
        • Samizo K.
        • Kawabe E.
        • Hinotsu S.
        • et al.
        Comparison of losartan with ACE inhibitors and dihydropyridine calcium channel antagonists: a pilot study of prescription-event monitoring in Japan.
        Drug Saf. 2002; 25: 811-821
        • Riegel B.
        • Moser D.K.
        • Anker S.D.
        • et al.
        State of the science: promoting self-care in persons with heart fail ure: a scientific statement from the American Heart Association.
        Circulation. 2009; 120: 1141-1163
        • Bucca C.B.
        • Brussino L.
        • Battisti A.
        • et al.
        Diuretics in obstructive sleep apnea with diastolic heart failure.
        Chest. 2007; 132: 440-446
        • Ehrenberg B.L.
        • Lamon-Fava S.
        • Corbett K.E.
        • et al.
        Comparison of the effects of pravastatin and lovastatin on sleep disturbance in hypercholesterolemic subjects.
        Sleep. 1999; 22: 117-121
        • Keech A.C.
        • Armitage J.M.
        • Wallendszus K.R.
        • et al.
        Absence of effects of prolonged simvastatin therapy on nocturnal sleep in a large randomized placebo- controlled study. Oxford Cholesterol Study Group.
        Br J Clin Pharmacol. 1996; 42: 483-490
        • Meixner R.
        • Gerhardstein R.
        • Day R.
        • et al.
        The alerting effects of dexamethasone.
        Psychophysiology. 2003; 40: 254-259
        • Friess E.
        • Tagaya H.
        • Grethe C.
        • et al.
        Acute cortisol administration promotes sleep intensity in man.
        Neuropsychopharmacology. 2004; 29: 598-604
        • Vgontzas A.N.
        • Bixler E.O.
        • Lin H.M.
        • et al.
        Chronic insomnia is associated with nyctohermeral activation of the hypothalamic-pituitary-adrenal axis: clinical implications.
        J Clin Endocrinol Metab. 2001; 86: 3787-3794
        • Rodenbeck A.
        • Huether G.
        • Ruther E.
        • et al.
        Interactions between evening and nocturnal cortisol secretion and sleep parameters in patients with severe chronic primary insomnia.
        Neurosci Lett. 2002; 324: 159-163
        • Chrousos G.A.
        • Kattah J.C.
        • Beck R.W.
        • et al.
        Side effects of glucocorticoid treatment. Experience of the optic neuritis treatment trial.
        JAMA. 1993; 269: 2110-2112
        • Lunn M.
        • Craig T.
        Rhinitis and sleep.
        Sleep Med Rev. 2011; 15: 293-299
        • Rosen G.
        • Harris A.K.
        • Liu M.
        • et al.
        The effects of Dexamethasone on sleep in young children with Acute Lymphoblastic Leukemia.
        Sleep Med. 2015; 16: 503-509
        • Steiger A.
        Sleep and the hypothalamo-pituitary- adrenocortical system.
        Sleep Med Rev. 2002; 6: 125-138
        • Krueger K.
        • Rector D.
        • Churchill L.
        Sleep and cytokines.
        Sleep Med Clin. 2007; 2: 161-169
        • Bryant P.
        • Trinder J.
        • Curtis N.
        Sick and tired: does sleep have a vital role in the immune system?.
        Nat Rev Immunol. 2004; 4: 457-467
        • Vassallo R.
        • Lipsky J.J.
        Theophylline: recent advances in the understanding of its mode of action and uses in clinical practice.
        Mayo Clin Proc. 1998; 73: 346-354
        • Smith P.L.
        • Schwartz A.R.
        The effect of theophylline on sleep in normal subjects.
        Chest. 1993; 103: 5-6
        • Fitzpatrick M.F.
        • Engleman H.M.
        • Boellert F.
        • et al.
        Effect of therapeutic theophylline levels on the sleep quality and daytime cognitive performance of normal subjects.
        Am Rev Respir Dis. 1992; 145: 1355-1358
        • Kaplan J.
        • Fredrickson P.A.
        • Renaux S.A.
        • et al.
        Theophylline effect on sleep in normal subjects.
        Chest. 1993; 103: 193-195
        • Roehrs T.
        • Merlotti L.
        • Halpin D.
        • et al.
        Effects of theophylline on nocturnal sleep and daytime sleepiness/alertness.
        Chest. 1995; 108: 382-387
        • Avital A.
        • Sanchez I.
        • Holbrow J.
        • et al.
        Effect of theophylline on lung function tests, sleep quality, and nighttime SaO2 in children with cystic fibrosis.
        Am Rev Respir Dis. 1991; 144: 1245-1249
        • Stein M.A.
        • Krasowski M.
        • Leventhal B.L.
        • et al.
        Behavioral and cognitive effects of methylxanthines. A meta-analysis of theophylline and caffeine.
        Arch Pediatr Adolesc Med. 1996; 150: 284-288
        • Janson C.
        • Gislason T.
        • Boman G.
        • et al.
        Sleep disturbances in patients with asthma.
        Respir Med. 1990; 84: 37-42
        • Mulloy E.
        • McNicholas W.T.
        Theophylline improves gas exchange during rest, exercise, and sleep in severe chronic obstructive pulmonary disease.
        Am Rev Respir Dis. 1993; 148: 1030-1036
        • Novak M.
        • Shapiro C.M.
        Drug-induced sleep disturbances. Focus on nonpsychotropic medications.
        Drug Saf. 1997; 16: 133-149
        • Jiménez J.A.
        • Greenberg B.H.
        • Mills P.J.
        Effects of heart failure and its pharmacological management on sleep.
        Drug Discov Today Dis Models. 2011; 8: 161-166