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Circadian Rhythm Sleep–Wake Disorders in Older Adults

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      References

        • Schrader H.
        • Bovim G.
        • Sand T.
        The prevalence of delayed and advanced sleep phase syndromes.
        J Sleep Res. 1993; 2: 51-55
        • Barion A.
        • Zee P.C.
        A clinical approach to circadian rhythm sleep disorders.
        Sleep Med. 2007; 8: 566-577
        • American Academy of Sleep Medicine
        International classification of sleep disorders.
        American Academy of Sleep Medicine, Darien, IL2014
        • Duffy J.F.
        • Abbott S.M.
        • Burgess H.J.
        • et al.
        Workshop report. Circadian rhythm sleep-wake disorders: gaps and opportunities.
        Sleep. 2021; 44
        • Czeisler C.A.
        • Klerman E.B.
        Circadian and sleep-dependent regulation of hormone release in humans.
        Recent Prog Horm Res. 1999; 54: 97-132
        • Czeisler C.A.
        • Gooley J.J.
        Sleep and circadian rhythms in humans.
        Cold Spring Harb Symp Quant Biol. 2007; 72: 579-597
        • Czeisler C.A.
        • Buxton O.M.
        Human circadian timing system and sleep-wake regulation.
        in: Kryger M.H. Roth T. Dement W.C. Principles and practice of sleep medicine. 6th ed. W.B. Saunders Company, Philadelphia2017: 362-376
        • Ko C.H.
        • Takahashi J.S.
        Molecular components of the mammalian circadian clock.
        Hum Mol Genet. 2006; 15: R271-R277
        • Dibner C.
        • Schibler U.
        • Albrecht U.
        The mammalian circadian timing system: organization and coordination of central and peripheral clocks.
        Annu Rev Physiol. 2010; 72: 517-549
        • Menaker M.
        • Takahashi J.S.
        • Eskin A.
        The physiology of circadian pacemakers.
        Annu Rev Physiol. 1978; 40: 501-526
        • DeCoursey P.J.
        Survival value of suprachiasmatic nuclei (SCN) in four wild sciurid rodents.
        Behav Neurosci. 2014; 128: 240-249
        • Duffy J.F.
        • Cain S.W.
        • Chang A.M.
        • et al.
        Sex difference in the near-24-hour intrinsic period of the human circadian timing system.
        Proc Natl Acad Sci U S A. 2011; 108: 15602-15608
        • Lockley S.W.
        • Arendt J.
        • Skene D.J.
        Visual impairment and circadian rhythm disorders.
        Dialogues Clin Neurosci. 2007; 9: 301-314
        • Czeisler C.A.
        • Dijk D.J.
        Human circadian physiology and sleep-wake regulation.
        in: Takahashi J.S. Turek F.W. Moore R.Y. Handbook of behavioral neurobiology: circadian clocks. Plenum Publishing Co., New York2001: 531-569
        • Dijk D.J.
        • Czeisler C.A.
        Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans.
        J Neurosci. 1995; 15: 3526-3538
        • Dijk D.J.
        • Duffy J.F.
        • Riel E.
        • et al.
        Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms.
        J Physiol. 1999; 516: 611-627
        • Luckhaupt S.E.
        Short sleep duration among workers -- United States, 2010. MMWR.
        Morb Mortal Wkly Rep. 2012; 61: 281-285
        • Duffy J.F.
        • Zitting K.M.
        • Chinoy E.D.
        Aging and circadian rhythms.
        Sleep Med Clin. 2015; 10: 423-434
        • Engelberth R.C.G.J.
        • Bezerra de Pontes A.L.
        • Porto Fiuza F.
        • et al.
        Changes in the suprachiasmatic nucleus during aging: implications for biological rhythms.
        Psychol Neurosci. 2013; 6: 287-297
        • Duffy J.F.
        • Dijk D.J.
        • Klerman E.B.
        • et al.
        Later endogenous circadian temperature nadir relative to an earlier wake time in older people.
        Am J Physiol. 1998; 275: R1478-R1487
        • Dijk D.J.
        • Duffy J.F.
        • Czeisler C.A.
        Age-related increase in awakenings: impaired consolidation of nonREM sleep at all circadian phases.
        Sleep. 2001; 24: 565-577
        • Morgenthaler T.I.
        • Lee-Chiong T.
        • Alessi C.
        • et al.
        Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders.
        Sleep. 2007; 30: 1445-1459
        • Rahman S.A.
        • Kayumov L.
        • Tchmoutina E.A.
        • et al.
        Clinical efficacy of dim light melatonin onset testing in diagnosing delayed sleep phase syndrome.
        Sleep Med. 2009; 10: 549-555
        • Foley D.J.
        • Monjan A.A.
        • Brown S.L.
        • et al.
        Sleep complaints among elderly persons: an epidemiologic study of three communities.
        Sleep. 1995; 18: 425-432
        • Foley D.
        • Ancoli-Israel S.
        • Britz P.
        • et al.
        Sleep disturbances and chronic disease in older adults: results of the 2003 national sleep foundation sleep in America survey.
        J Psychosom Res. 2004; 56: 497-502
        • Roenneberg T.
        • Kuehnle T.
        • Pramstaller P.P.
        • et al.
        A marker for the end of adolescence.
        Curr Biol. 2004; 14: R1038-R1039
        • Sack R.L.
        • Auckley D.
        • Auger R.R.
        • et al.
        Circadian rhythm sleep disorders: part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder, and irregular sleep-wake rhythm. an American academy of sleep medicine review.
        Sleep. 2007; 30: 1484-1501
        • Curtis B.J.
        • Ashbrook L.H.
        • Young T.
        • et al.
        Extreme morning chronotypes are often familial and not exceedingly rare: the estimated prevalence of advanced sleep phase, familial advanced sleep phase, and advanced sleep-wake phase disorder in a sleep clinic population.
        Sleep. 2019; 42
        • Monk T.H.
        • Buysse D.J.
        Chronotype, bed timing and total sleep time in seniors.
        Chronobiol Int. 2014; 31: 655-659
        • Uchiyama M.
        • Lockley S.W.
        Non-24-hour sleep-wake rhythm disorder in sighted and blind patients.
        Sleep Med Clin. 2015; 10: 495-516
        • Zee P.C.
        • Vitiello M.V.
        Circadian rhythm sleep disorder: irregular sleep wake rhythm type.
        Sleep Med Clin. 2009; 4: 213-218
        • Ancoli-Israel S.
        • Klauber M.R.
        • Jones D.W.
        • et al.
        Variations in circadian rhythms of activity, sleep, and light exposure related to dementia in nursing-home patients.
        Sleep. 1997; 20: 18-23
        • Sack R.L.
        • Auckley D.
        • Auger R.R.
        • et al.
        Circadian rhythm sleep disorders: part I, basic principles, shift work and jet lag disorders. an American academy of sleep medicine review.
        Sleep. 2007; 30: 1460-1483
        • Duffy J.F.
        Shift work and aging: roles of sleep and circadian rhythms.
        Clin Occup Environ Med. 2003; 3: 311-332
        • Schuster M.
        • Oberlinner C.
        • Claus M.
        Shift-specific associations between age, chronotype and sleep duration.
        Chronobiol Int. 2019; 36: 784-795
        • Härmä M.
        • Tenkanen L.
        • Sjöblom T.
        • et al.
        Combined effects of shift work and life-style on the prevalence of insomnia, sleep deprivation and daytime sleepiness.
        Scand J Work Environ Health. 1998; 24: 300-307
        • Pye J.
        • Phillips A.J.
        • Cain S.W.
        • et al.
        Irregular sleep-wake patterns in older adults with current or remitted depression.
        J Affect Disord. 2021; 281: 431-437
        • Hoyos C.M.
        • Gordon C.
        • Terpening Z.
        • et al.
        Circadian rhythm and sleep alterations in older people with lifetime depression: a case-control study.
        BMC Psychiatry. 2020; 20: 192
        • Blackwell T.
        • Yaffe K.
        • Ancoli-Israel S.
        • et al.
        Poor sleep is associated with impaired cognitive function in older women: the study of osteoporotic fractures.
        J Gerontol A Biol Sci Med Sci. 2006; 61: 405-410
        • Yaffe K.
        • Blackwell T.
        • Barnes D.E.
        • et al.
        Preclinical cognitive decline and subsequent sleep disturbance in older women.
        Neurology. 2007; 69: 237-242
        • Tranah G.J.
        • Blackwell T.
        • Ancoli-Israel S.
        • et al.
        Circadian activity rhythms and mortality: the study of osteoporotic fractures.
        J Am Geriatr Soc. 2010; 58: 282-291
        • Tranah G.J.
        • Blackwell T.
        • Stone K.L.
        • et al.
        Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women.
        Ann Neurol. 2011; 70: 722-732
        • Lim A.S.
        • Yu L.
        • Costa M.D.
        • et al.
        Increased fragmentation of rest-activity patterns is associated with a characteristic pattern of cognitive impairment in older individuals.
        Sleep. 2012; 35: 633-640B
        • Blackwell T.
        • Yaffe K.
        • Laffan A.
        • et al.
        Associations of objectively and subjectively measured sleep quality with subsequent cognitive decline in older community-dwelling men: the MrOS sleep study.
        Sleep. 2014; 37: 655-663
        • Diem S.J.
        • Blackwell T.L.
        • Stone K.L.
        • et al.
        Measures of sleep-wake patterns and risk of mild cognitive impairment or dementia in older women.
        Am J Geriatr Psychiatry. 2016; 24: 248-258
        • Leng Y.
        • Blackwell T.
        • Cawthon P.M.
        • et al.
        Association of circadian abnormalities in older adults with an increased risk of developing Parkinson disease.
        JAMA Neurol. 2020; 77: 1270-1278
        • Kang J.E.
        • Lim M.M.
        • Bateman R.J.
        • et al.
        Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle.
        Science. 2009; 326: 1005-1007
        • Roh J.H.
        • Huang Y.
        • Bero A.W.
        • et al.
        Disruption of the sleep-wake cycle and diurnal fluctuation of beta-amyloid in mice with Alzheimer's Disease pathology.
        Sci Transl Med. 2013; 4: 1-10
        • Holth J.K.
        • Fritschi S.K.
        • Wang C.
        • et al.
        The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans.
        Science. 2019; 363: 880-884
        • Xie L.
        • Kang H.
        • Xu Q.
        • et al.
        Sleep drives metabolite clearance from the adult brain.
        Science. 2013; 342: 373-377
        • Li J.
        • Somers V.K.
        • Lopez-Jimenez F.
        • et al.
        Demographic characteristics associated with circadian rest-activity rhythm patterns: a cross-sectional study.
        Int J Behav Nutr Phys Act. 2021; 18: 107
        • Van Someren E.J.
        Actigraphic monitoring of sleep and circadian rhythms.
        Handb Clin Neurol. 2011; 98: 55-63
        • Oosterman J.M.
        • van Someren E.J.
        • Vogels R.L.
        • et al.
        Fragmentation of the rest-activity rhythm correlates with age-related cognitive deficits.
        J Sleep Res. 2009; 18: 129-135
        • Wang J.L.
        • Lim A.S.
        • Chiang W.Y.
        • et al.
        Suprachiasmatic neuron numbers and rest-activity circadian rhythms in older humans.
        Ann Neurol. 2015; 78: 317-322
        • Musiek E.S.
        • Bhimasani M.
        • Zangrilli M.A.
        • et al.
        Circadian rest-activity pattern changes in aging and preclinical Alzheimer disease.
        JAMA Neurol. 2018; 75: 582-590
        • Li P.
        • Gao L.
        • Gaba A.
        • et al.
        Circadian disturbances in Alzheimer's disease progression: a prospective observational cohort study of community-based older adults.
        Lancet Healthy Longev. 2020; 1: e96-e105
        • Satlin A.
        • Volicer L.
        • Stopa E.G.
        • et al.
        Circadian locomotor activity and core-body temperature rhythms in Alzheimer's disease.
        Neurobiol Aging. 1995; 16: 765-771
        • Harper D.G.
        • Volicer L.
        • Stopa E.G.
        • et al.
        Disturbance of endogenous circadian rhythm in aging and Alzheimer disease.
        Am J Geriatr Psychiatry. 2005; 13: 359-368
        • Inouye S.K.
        • Marcantonio E.R.
        • Kosar C.M.
        • et al.
        The short-term and long-term relationship between delirium and cognitive trajectory in older surgical patients.
        Alzheimers Dement. 2016; 12: 766-775
        • Swaab D.F.
        • Fliers E.
        • Partiman T.S.
        The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia.
        Brain Res. 1985; 342: 37-44
        • Baloyannis S.J.
        • Mavroudis I.
        • Mitilineos D.
        • et al.
        The hypothalamus in Alzheimer's disease: a golgi and electron microscope study.
        Am J Alzheimers Dis Other Demen. 2015; 30: 478-487
        • Joyce D.S.
        • Feigl B.
        • Kerr G.
        • et al.
        Melanopsin-mediated pupil function is impaired in Parkinson's disease.
        Sci Rep. 2018; 8: 7796
        • La Morgia C.
        • Ross-Cisneros F.N.
        • Sadun A.A.
        • et al.
        Retinal ganglion cells and circadian rhythms in Alzheimer's disease, Parkinson's disease, and beyond.
        Front Neurol. 2017; 8: 162
        • Harper D.G.
        • Stopa E.G.
        • McKee A.C.
        • et al.
        Differential circadian rhythm disturbances in men with Alzheimer disease and frontotemporal degeneration.
        Arch Gen Psychiatry. 2001; 58: 353-360
        • Gao L.
        • Liu Y.
        • Li X.
        • et al.
        Abnormal retinal nerve fiber layer thickness and macula lutea in patients with mild cognitive impairment and Alzheimer's disease.
        Arch Gerontol Geriatr. 2015; 60: 162-167
        • Coppola G.
        • Di Renzo A.
        • Ziccardi L.
        • et al.
        Optical coherence tomography in Alzheimer's disease: a meta-analysis.
        PLoS one. 2015; 10: e0134750
        • La Morgia C.
        • Ross-Cisneros F.N.
        • Koronyo Y.
        • et al.
        Melanopsin retinal ganglion cell loss in Alzheimer disease.
        Ann Neurol. 2016; 79: 90-109
        • Chahine L.M.
        • Amara A.W.
        • Videnovic A.
        A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015.
        Sleep Med Rev. 2016; 35 (epub ahead of print): 33-50
        • Gros P.
        • Videnovic A.
        Overview of sleep and circadian rhythm disorders in Parkinson disease.
        Clin Geriatr Med. 2020; 36: 119-130
        • Videnovic A.
        • Noble C.
        • Reid K.J.
        • et al.
        Circadian melatonin rhythm and excessive daytime sleepiness in Parkinson disease.
        JAMA Neurol. 2014; 71: 463-469
        • Bordet R.
        • Devos D.
        • Brique S.
        • et al.
        Study of circadian melatonin secretion pattern at different stages of Parkinson's disease.
        Clin Neuropharmacol. 2003; 26: 65-72
        • Walsh C.M.
        • Ruoff L.
        • Varbel J.
        • et al.
        Rest-activity rhythm disruption in progressive supranuclear palsy.
        Sleep Med. 2016; 22: 50-56
        • Aziz N.A.
        • Pijl H.
        • Frolich M.
        • et al.
        Delayed onset of the diurnal melatonin rise in patients with Huntington's disease.
        J Neurol. 2009; 256: 1961-1965
        • Morton A.J.
        • Rudiger S.R.
        • Wood N.I.
        • et al.
        Early and progressive circadian abnormalities in Huntington's disease sheep are unmasked by social environment.
        Hum Mol Genet. 2014; 23: 3375-3383
        • van Wamelen D.J.
        • Aziz N.A.
        • Anink J.J.
        • et al.
        Suprachiasmatic nucleus neuropeptide expression in patients with Huntington's Disease.
        Sleep. 2013; 36: 117-125
        • Czeisler C.A.
        • Allan J.S.
        • Strogatz S.H.
        • et al.
        Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle.
        Science. 1986; 233: 667-671
        • Duffy J.F.
        • Zeitzer J.M.
        • Czeisler C.A.
        Decreased sensitivity to phase-delaying effects of moderate intensity light in older subjects.
        Neurobiol Aging. 2007; 28: 799-807
        • Kim S.J.
        • Benloucif S.
        • Reid K.J.
        • et al.
        Phase-shifting response to light in older adults.
        J Physiol. 2014; 592: 189-202
        • Benloucif S.
        • Green K.
        • L'Hermite-Baleriaux M.
        • et al.
        Responsiveness of the aging circadian clock to light.
        Neurobiol Aging. 2006; 27: 1870-1879
        • Klerman E.B.
        • Duffy J.F.
        • Dijk D.J.
        • et al.
        Circadian phase resetting in older people by ocular bright light exposure.
        J Investig Med. 2001; 49: 30-40
        • Khalsa S.B.S.
        • Jewett M.E.
        • Cajochen C.
        • et al.
        A phase response curve to single bright light pulses in human subjects.
        J Physiol. 2003; 549: 945-952
        • Chang A.M.
        • Santhi N.
        • St Hilaire M.
        • et al.
        Human responses to bright light of different durations.
        J Physiol. 2012; 590: 3103-3112
        • Dewan K.
        • Benloucif S.
        • Reid K.
        • et al.
        Light-induced changes of the circadian clock of humans: increasing duration is more effective than increasing light intensity.
        Sleep. 2011; 34: 593-599
        • Najjar R.P.
        • Zeitzer J.M.
        Temporal integration of light flashes by the human circadian system.
        J Clin Invest. 2016; 126: 938-947
        • Herljevic M.
        • Middleton B.
        • Thapan K.
        • et al.
        Light-induced melatonin suppression: age-related reduction in response to short wavelength light.
        Exp Gerontol. 2005; 40: 237-242
        • Sletten T.L.
        • Revell V.L.
        • Middleton B.
        • et al.
        Age-related changes in acute and phase-advancing responses to monochromatic light.
        J Biol Rhythms. 2009; 24: 73-84
        • Kessel L.
        • Siganos G.
        • Jorgensen T.
        • et al.
        Sleep disturbances are related to decreased transmission of blue light to the retina caused by lens yellowing.
        Sleep. 2011; 34: 1215-1219
        • Campbell S.S.
        • Dawson D.
        • Anderson M.W.
        Alleviation of sleep maintenance insomnia with timed exposure to bright light.
        J Am Geriatr Soc. 1993; 41: 829-836
        • Suhner A.G.
        • Murphy P.J.
        • Campbell S.S.
        Failure of timed bright light exposure to alleviate age-related sleep maintenance insomnia.
        J Am Geriatr Soc. 2002; 50: 617-623
        • Pallesen S.
        • Nordhus I.H.
        • Skelton S.H.
        • et al.
        Bright light treatment has limited effect in subjects over 55 years with mild early morning awakening.
        Percept Mot Skills. 2005; 101: 759-770
        • Auger R.R.
        • Burgess H.J.
        • Emens J.S.
        • et al.
        Clinical practice guideline for the treatment of intrinsic circadian rhythm sleep-wake disorders: advanced sleep-wake phase disorder (ASWPD), delayed sleep-wake phase disorder (DSWPD), non-24-hour sleep-wake rhythm disorder (N24SWD), and irregular sleep-wake rhythm disorder (ISWRD). An update for 2015: an American Academy of sleep medicine clinical practice guideline.
        J Clin Sleep Med. 2015; 11: 1199-1236
        • Pollak C.P.
        • Perlick D.
        Sleep problems and institutionalization of the elderly.
        J Geriatr Psychiatry Neurol. 1991; 4: 204-210
        • Pollak C.P.
        • Perlick D.
        • Linsner J.P.
        • et al.
        Sleep problems in the community elderly as predictors of death and nursing home placement.
        J Community Health. 1990; 15: 123-135
        • Mishima K.
        • Okawa M.
        • Hishikaa Y.
        • et al.
        Morning bright light therapy for sleep and behaviour disorders in elderly patients with dementia.
        Acta Psychiatr Scand. 1994; 89: 1-7
        • Satlin A.
        • Volicer L.
        • Ross V.
        • et al.
        Bright light treatment of behavioral and sleep disturbances in patients with Alzheimer's disease.
        Am J Psychiatry. 1992; 149: 1028-1032
        • Figueiro M.G.
        • Plitnick B.
        • Roohan C.
        • et al.
        Effects of a tailored lighting intervention on sleep quality, rest-activity, mood, and behavior in older adults with Alzheimer disease and related dementias: a randomized clinical trial.
        J Clin Sleep Med. 2019; 15: 1757-1767
        • Endo T.
        • Matsumura R.
        • Tokuda I.T.
        • et al.
        Bright light improves sleep in patients with Parkinson's disease: possible role of circadian restoration.
        Sci Rep. 2020; 10: 7982
        • Dowling G.A.
        • Burr R.L.
        • Van Someren E.J.
        • et al.
        Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease.
        J Am Geriatr Soc. 2008; 56: 239-246
        • Riemersma-van der Lek R.F.
        • Swaab D.F.
        • Twisk J.
        • et al.
        Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
        JAMA. 2008; 299: 2642-2655
        • Figueiro M.G.
        • Plitnick B.A.
        • Lok A.
        • et al.
        Tailored lighting intervention improves measures of sleep, depression, and agitation in persons with Alzheimer's disease and related dementia living in long-term care facilities.
        Clin Interv Aging. 2014; 9: 1527-1537
        • Alessi C.A.
        • Martin J.L.
        • Webber A.P.
        • et al.
        Randomized, controlled trial of a nonpharmacological intervention to improve abnormal sleep/wake patterns in nursing home residents.
        J Am Geriatr Soc. 2005; 53: 803-810
        • Clendon J.
        • Walker L.
        Nurses aged over 50 years and their experiences of shift work.
        J Nurs Manag. 2013; 21: 903-913
        • Richter K.
        • Acker J.
        • Adam S.
        • et al.
        Prevention of fatigue and insomnia in shift workers-a review of non-pharmacological measures.
        EPMA J. 2016; 7: 16
        • Crowley S.J.
        • Lee C.
        • Tseng C.Y.
        • et al.
        Combinations of bright light, scheduled dark, sunglasses, and melatonin to facilitate circadian entrainment to night shift work.
        J Biol Rhythms. 2003; 18: 513-523
        • Walsh J.K.
        • Muehlbach M.J.
        • Schweitzer P.K.
        Hypnotics and caffeine as countermeasures for shiftwork-related sleepiness and sleep disturbance.
        J Sleep Res. 1995; 4: 80-83
        • Chinoy E.D.
        • Harris M.P.
        • Kim M.J.
        • et al.
        Scheduled evening sleep and enhanced lighting improve adaptation to night shift work in older adults.
        Occup Environ Med. 2016; 73: 869-876
        • Isherwood C.M.
        • Chinoy E.D.
        • Murphy A.S.
        • et al.
        Scheduled afternoon-evening sleep leads to better night shift performance in older adults.
        Occup Environ Med. 2020; 77: 179-184
        • St Hilaire M.A.
        • Lammers-van der Holst H.M.
        • Chinoy E.D.
        • et al.
        Prediction of individual differences in circadian adaptation to night work among older adults: application of a mathematical model using individual sleep-wake and light exposure data.
        Chronobiol Int. 2020; 37: 1404-1411
        • Karoly L.
        • Panis C.
        Shifting demographic patterns shaping the future workforce. The 21st century at work: forces shaping the future workforce and workplace in the United States.
        RAND Corporation, Santa Monica (CA)2004
        • Fung C.H.
        • Vitiello M.V.
        • Alessi C.A.
        • et al.
        Report and research agenda of the American geriatrics society and national institute on aging bedside-to-bench conference on sleep, circadian rhythms, and aging: new avenues for improving brain health, physical health, and functioning.
        J Am Geriatr Soc. 2016; 64: e238-e247