Circadian Disruption in Psychiatric Disorders

Published:September 16, 2015DOI:https://doi.org/10.1016/j.jsmc.2015.07.004

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Sleep Medicine Clinics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Sutton E.L.
        Psychiatric disorders and sleep issues.
        Med Clin North Am. 2014; 98: 1123-1143
        • Murphy M.J.
        • Peterson M.J.
        Sleep disturbances in depression.
        Sleep Med Clin. 2015; 10: 17-23
        • Harvey A.G.
        Sleep and circadian rhythms in bipolar disorder: seeking synchrony, harmony, and regulation.
        Am J Psychiatry. 2008; 165: 820-829
        • Dolsen M.R.
        • Asarnow L.D.
        • Harvey A.G.
        Insomnia as a transdiagnostic process in psychiatric disorders.
        Curr Psychiatry Rep. 2014; 16: 0471
        • Benson K.L.
        Sleep in schizophrenia: pathology and treatment.
        Sleep Med Clin. 2015; 10: 49-55
        • Dibner C.
        • Schibler U.
        • Albrecht U.
        The mammalian circadian timing system: organization and coordination of central and peripheral clocks.
        Annu Rev Physiol. 2010; 72: 517-549
        • Reid K.J.
        • Zee P.C.
        Circadian rhythm disorders.
        Semin Neurol. 2009; 29: 393-405
        • Partch C.L.
        • Green C.B.
        • Takahashi J.S.
        Molecular architecture of the mammalian circadian clock.
        Trends Cell Biol. 2014; 24: 90-99
        • Evans J.A.
        • Davidson A.J.
        Health consequences of circadian disruption in humans and animal models.
        Prog Mol Biol Transl Sci. 2013; 119: 283-323
        • Reddy A.B.
        • Rey G.
        Metabolic and nontranscriptional circadian clocks: eukaryotes.
        Annu Rev Biochem. 2014; 83: 165-189
        • Albers H.E.
        • Ferris C.F.
        Neuropeptide Y: role in light-dark cycle entrainment of hamster circadian rhythms.
        Neurosci Lett. 1984; 50: 163-168
        • Biello S.M.
        • Janik D.
        • Mrosovsky N.
        Neuropeptide Y and behaviorally induced phase shifts.
        Neuroscience. 1994; 62: 273-279
        • Card J.P.
        • Moore R.Y.
        Ventral lateral geniculate nucleus efferents to the rat suprachiasmatic nucleus exhibit avian pancreatic polypeptide-like immunoreactivity.
        J Comp Neurol. 1982; 206: 390-396
        • Gamble K.L.
        • Allen G.C.
        • Zhou T.
        • et al.
        Gastrin-releasing peptide mediates light-like resetting of the suprachiasmatic nucleus circadian pacemaker through cAMP response element-binding protein and Per1 activation.
        J Neurosci. 2007; 27: 12078-12087
        • Sheward W.J.
        • Maywood E.S.
        • French K.L.
        • et al.
        Entrainment to feeding but not to light: circadian phenotype of VPAC2 receptor-null mice.
        J Neurosci. 2007; 27: 4351-4358
        • Silver R.
        • Kriegsfeld L.J.
        Circadian rhythms have broad implications for understanding brain and behavior.
        Eur J Neurosci. 2014; 39: 1866-1880
        • Mavroudis P.D.
        • Scheff J.D.
        • Calvano S.E.
        • et al.
        Entrainment of peripheral clock genes by cortisol.
        Physiol Genomics. 2012; 44: 607-621
        • Maywood E.S.
        • Chesham J.E.
        • O'Brien J.A.
        • et al.
        A diversity of paracrine signals sustains molecular circadian cycling in suprachiasmatic nucleus circuits.
        Proc Natl Acad Sci U S A. 2011; 108: 14306-14311
        • Nicolaides N.C.
        • Charmandari E.
        • Chrousos G.P.
        • et al.
        Circadian endocrine rhythms: the hypothalamic-pituitary-adrenal axis and its actions.
        Ann N Y Acad Sci. 2014; 1318: 71-80
        • Malek Z.S.
        • Sage D.
        • Pevet P.
        • et al.
        Daily rhythm of tryptophan hydroxylase-2 messenger ribonucleic acid within raphe neurons is induced by corticoid daily surge and modulated by enhanced locomotor activity.
        Endocrinology. 2007; 148: 5165-5172
        • Byrne E.M.
        • Heath A.C.
        • Madden P.A.
        • et al.
        Testing the role of circadian genes in conferring risk for psychiatric disorders.
        Am J Med Genet B Neuropsychiatr Genet. 2014; 165B: 254-260
        • Gold P.W.
        The organization of the stress system and its dysregulation in depressive illness.
        Mol Psychiatry. 2015; 20: 32-47
        • Weinrib A.Z.
        • Sephton S.E.
        • Degeest K.
        • et al.
        Diurnal cortisol dysregulation, functional disability, and depression in women with ovarian cancer.
        Cancer. 2010; 116: 4410-4419
        • Cizza G.
        • Ronsaville D.S.
        • Kleitz H.
        • et al.
        Clinical subtypes of depression are associated with specific metabolic parameters and circadian endocrine profiles in women: the Power study.
        PLoS One. 2012; 7: e28912
        • Heaney J.L.
        • Phillips A.C.
        • Carroll D.
        Ageing, depression, anxiety, social support and the diurnal rhythm and awakening response of salivary cortisol.
        Int J Psychophysiol. 2010; 78: 201-208
        • Vreeburg S.A.
        • Hoogendijk W.J.
        • van Pelt J.
        • et al.
        Major depressive disorder and hypothalamic-pituitary-adrenal axis activity: results from a large cohort study.
        Arch Gen Psychiatry. 2009; 66: 617-626
        • Sudheimer K.
        • Keller J.
        • Gomez R.
        • et al.
        Decreased hypothalamic functional connectivity with subgenual cortex in psychotic major depression.
        Neuropsychopharmacology. 2015; 40: 849-860
        • Benloucif S.
        • Burgess H.J.
        • Klerman E.B.
        • et al.
        Measuring melatonin in humans.
        J Clin Sleep Med. 2008; 4: 66-69
        • Emens J.
        • Lewy A.
        • Kinzie J.M.
        • et al.
        Circadian misalignment in major depressive disorder.
        Psychiatry Res. 2009; 168: 259-261
        • Hasler B.P.
        • Buysse D.J.
        • Kupfer D.J.
        • et al.
        Phase relationships between core body temperature, melatonin, and sleep are associated with depression severity: further evidence for circadian misalignment in non-seasonal depression.
        Psychiatry Res. 2010; 178: 205-207
        • Emens J.S.
        • Yuhas K.
        • Rough J.
        • et al.
        Phase angle of entrainment in morning- and evening-types under naturalistic conditions.
        Chronobiol Int. 2009; 26: 474-493
        • MacIsaac S.E.
        • Carvalho A.F.
        • Cha D.S.
        • et al.
        The mechanism, efficacy, and tolerability profile of agomelatine.
        Expert Opin Pharmacother. 2014; 15: 259-274
        • Kennedy S.H.
        • Kutcher S.P.
        • Ralevski E.
        • et al.
        Nocturnal melatonin and 24-hour 6-sulphatoxymelatonin levels in various phases of bipolar affective disorder.
        Psychiatry Res. 1996; 63: 219-222
        • Novakova M.
        • Prasko J.
        • Latalova K.
        • et al.
        The circadian system of patients with bipolar disorder differs in episodes of mania and depression.
        Bipolar Disord. 2015; 17: 303-314
        • Walker M.P.
        Sleep, memory and emotion.
        Prog Brain Res. 2010; 185: 49-68
        • Soreca I.
        Circadian rhythms and sleep in bipolar disorder: implications for pathophysiology and treatment.
        Curr Opin Psychiatry. 2014; 27: 467-471
        • Kaplan K.A.
        • McGlinchey E.L.
        • Soehner A.
        • et al.
        Hypersomnia subtypes, sleep and relapse in bipolar disorder.
        Psychol Med. 2015; 45: 1751-1763
        • Boudebesse C.
        • Geoffroy P.A.
        • Bellivier F.
        • et al.
        Correlations between objective and subjective sleep and circadian markers in remitted patients with bipolar disorder.
        Chronobiol Int. 2014; 31: 698-704
        • Geoffroy P.A.
        • Scott J.
        • Boudebesse C.
        • et al.
        Sleep in patients with remitted bipolar disorders: a meta-analysis of actigraphy studies.
        Acta Psychiatr Scand. 2015; 131: 89-99
        • Ng T.H.
        • Chung K.F.
        • Ho F.Y.
        • et al.
        Sleep-wake disturbance in interepisode bipolar disorder and high-risk individuals: a systematic review and meta-analysis.
        Sleep Med Rev. 2015; 20: 46-58
        • Harvey A.G.
        • Talbot L.S.
        • Gershon A.
        Sleep disturbance in bipolar disorder across the lifespan.
        Clin Psychol (New York). 2009; 16: 256-277
        • Benca R.
        • Duncan M.J.
        • Frank E.
        • et al.
        Biological rhythms, higher brain function, and behavior: gaps, opportunities, and challenges.
        Brain Res Rev. 2009; 62: 57-70
        • Schwartz J.R.
        • Roth T.
        Neurophysiology of sleep and wakefulness: basic science and clinical implications.
        Curr Neuropharmacol. 2008; 6: 367-378
        • Keshavan M.S.
        • Prasad K.M.
        • Montrose D.M.
        • et al.
        Sleep quality and architecture in quetiapine, risperidone, or never-treated schizophrenia patients.
        J Clin Psychopharmacol. 2007; 27: 703-705
        • Manoach D.S.
        • Demanuele C.
        • Wamsley E.J.
        • et al.
        Sleep spindle deficits in antipsychotic-naive early course schizophrenia and in non-psychotic first-degree relatives.
        Front Hum Neurosci. 2014; 8: 762
        • Poulin J.
        • Daoust A.M.
        • Forest G.
        • et al.
        Sleep architecture and its clinical correlates in first episode and neuroleptic-naive patients with schizophrenia.
        Schizophr Res. 2003; 62: 147-153
        • Wulff K.
        • Dijk D.J.
        • Middleton B.
        • et al.
        Sleep and circadian rhythm disruption in schizophrenia.
        Br J Psychiatry. 2012; 200: 308-316
        • Bromundt V.
        • Koster M.
        • Georgiev-Kill A.
        • et al.
        Sleep-wake cycles and cognitive functioning in schizophrenia.
        Br J Psychiatry. 2011; 198: 269-276
        • Bruno A.
        • Zoccali R.A.
        • Abenavoli E.
        • et al.
        Augmentation of clozapine with agomelatine in partial-responder schizophrenia: a 16-week, open-label, uncontrolled pilot study.
        J Clin Psychopharmacol. 2014; 34: 491-494
        • Bunney B.G.
        • Li J.Z.
        • Walsh D.M.
        • et al.
        Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder.
        Mol Psychiatry. 2015; 20: 48-55
        • Wu Y.H.
        • Ursinus J.
        • Zhou J.N.
        • et al.
        Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression.
        J Affect Disord. 2013; 148: 357-367
        • Pevet P.
        • Challet E.
        Melatonin: both master clock output and internal time-giver in the circadian clocks network.
        J Physiol Paris. 2011; 105: 170-182
        • Lavebratt C.
        • Sjoholm L.K.
        • Soronen P.
        • et al.
        CRY2 is associated with depression.
        PLoS One. 2010; 5: e9407
        • McCarthy M.J.
        • Wei H.
        • Marnoy Z.
        • et al.
        Genetic and clinical factors predict lithium's effects on PER2 gene expression rhythms in cells from bipolar disorder patients.
        Transl Psychiatry. 2013; 3: e318
        • Li S.X.
        • Liu L.J.
        • Xu L.Z.
        • et al.
        Diurnal alterations in circadian genes and peptides in major depressive disorder before and after escitalopram treatment.
        Psychoneuroendocrinology. 2013; 38: 2789-2799
        • Zhang R.
        • Lahens N.F.
        • Ballance H.I.
        • et al.
        A circadian gene expression atlas in mammals: implications for biology and medicine.
        Proc Natl Acad Sci U S A. 2014; 111: 16219-16224
        • Golden R.N.
        • Gaynes B.N.
        • Ekstrom R.D.
        • et al.
        The efficacy of light therapy in the treatment of mood disorders: a review and meta-analysis of the evidence.
        Am J Psychiatry. 2005; 162: 656-662
        • Benedetti F.
        • Colombo C.
        • Pontiggia A.
        • et al.
        Morning light treatment hastens the antidepressant effect of citalopram: a placebo-controlled trial.
        J Clin Psychiatry. 2003; 64: 648-653
        • Martiny K.
        • Lunde M.
        • Unden M.
        • et al.
        Adjunctive bright light in non-seasonal major depression: results from clinician-rated depression scales.
        Acta Psychiatr Scand. 2005; 112: 117-125
        • Martiny K.
        • Lunde M.
        • Unden M.
        • et al.
        Adjunctive bright light in non-seasonal major depression: results from patient-reported symptom and well-being scales.
        Acta Psychiatr Scand. 2005; 111: 453-459
        • Hubbard J.
        • Ruppert E.
        • Gropp C.M.
        • et al.
        Non-circadian direct effects of light on sleep and alertness: lessons from transgenic mouse models.
        Sleep Med Rev. 2013; 17: 445-452
        • Bedrosian T.A.
        • Nelson R.J.
        Influence of the modern light environment on mood.
        Mol Psychiatry. 2013; 18: 751-757
        • Bedrosian T.A.
        • Vaughn C.A.
        • Galan A.
        • et al.
        Nocturnal light exposure impairs affective responses in a wavelength-dependent manner.
        J Neurosci. 2013; 33: 13081-13087
        • Benedetti F.
        • Colombo C.
        Sleep deprivation in mood disorders.
        Neuropsychobiology. 2011; 64: 141-151
        • Wu J.C.
        • Bunney W.E.
        The biological basis of an antidepressant response to sleep deprivation and relapse: review and hypothesis.
        Am J Psychiatry. 1990; 147: 14-21
        • Dallaspezia S.
        • Benedetti F.
        Sleep deprivation therapy for depression.
        Curr Top Behav Neurosci. 2015; 25: 483-502
        • Nelson J.C.
        The STAR*D study: a four-course meal that leaves us wanting more.
        Am J Psychiatry. 2006; 163: 1864-1866
        • Price L.H.
        • Charney D.S.
        • Delgado P.L.
        • et al.
        Serotonin function and depression: neuroendocrine and mood responses to intravenous L-tryptophan in depressed patients and healthy comparison subjects.
        Am J Psychiatry. 1991; 148: 1518-1525
        • Deboer T.
        • Vansteensel M.J.
        • Detari L.
        • et al.
        Sleep states alter activity of suprachiasmatic nucleus neurons.
        Nat Neurosci. 2003; 6: 1086-1090
        • Ackermann K.
        • Plomp R.
        • Lao O.
        • et al.
        Effect of sleep deprivation on rhythms of clock gene expression and melatonin in humans.
        Chronobiol Int. 2013; 30: 901-909
        • Archer S.N.
        • Laing E.E.
        • Moller-Levet C.S.
        • et al.
        Mistimed sleep disrupts circadian regulation of the human transcriptome.
        Proc Natl Acad Sci U S A. 2014; 111: E682-E691
        • Moller-Levet C.S.
        • Archer S.N.
        • Bucca G.
        • et al.
        Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome.
        Proc Natl Acad Sci U S A. 2013; 110: E1132-E1141
        • Souetre E.
        • Salvati E.
        • Pringuey D.
        • et al.
        Antidepressant effects of the sleep/wake cycle phase advance. Preliminary report.
        J Affect Disord. 1987; 12: 41-46
        • Berger M.
        • Vollmann J.
        • Hohagen F.
        • et al.
        Sleep deprivation combined with consecutive sleep phase advance as a fast-acting therapy in depression: an open pilot trial in medicated and unmedicated patients.
        Am J Psychiatry. 1997; 154: 870-872
        • Echizenya M.
        • Suda H.
        • Takeshima M.
        • et al.
        Total sleep deprivation followed by sleep phase advance and bright light therapy in drug-resistant mood disorders.
        J Affect Disord. 2013; 144: 28-33
        • Martiny K.
        • Refsgaard E.
        • Lund V.
        • et al.
        A 9-week randomized trial comparing a chronotherapeutic intervention (wake and light therapy) to exercise in major depressive disorder patients treated with duloxetine.
        J Clin Psychiatry. 2012; 73: 1234-1242
        • Sahlem G.L.
        • Kalivas B.
        • Fox J.B.
        • et al.
        Adjunctive triple chronotherapy (combined total sleep deprivation, sleep phase advance, and bright light therapy) rapidly improves mood and suicidality in suicidal depressed inpatients: an open label pilot study.
        J Psychiatr Res. 2014; 59: 101-107
        • Frank E.
        • Kupfer D.J.
        • Thase M.E.
        • et al.
        Two-year outcomes for interpersonal and social rhythm therapy in individuals with bipolar I disorder.
        Arch Gen Psychiatry. 2005; 62: 996-1004
        • Miklowitz D.J.
        • Otto M.W.
        • Frank E.
        • et al.
        Psychosocial treatments for bipolar depression: a 1-year randomized trial from the systematic treatment enhancement program.
        Arch Gen Psychiatry. 2007; 64: 419-426
        • Inder M.L.
        • Crowe M.T.
        • Luty S.E.
        • et al.
        Randomized, controlled trial of interpersonal and social rhythm therapy for young people with bipolar disorder.
        Bipolar Disord. 2015; 17: 128-138
        • Geddes J.R.
        • Miklowitz D.J.
        Treatment of bipolar disorder.
        Lancet. 2013; 381: 1672-1682
        • Geoffroy P.A.
        • Bellivier F.
        • Leboyer M.
        • et al.
        Can the response to mood stabilizers be predicted in bipolar disorder?.
        Front Biosci (Elite Ed). 2014; 6: 120-138
        • Rybakowski J.K.
        Response to lithium in bipolar disorder: clinical and genetic findings.
        ACS Chem Neurosci. 2014; 5: 413-421
        • Fornaro M.
        • McCarthy M.J.
        • De Berardis D.
        • et al.
        Adjunctive agomelatine therapy in the treatment of acute bipolar II depression: a preliminary open label study.
        Neuropsychiatr Dis Treat. 2013; 9: 243-251
        • Stein D.J.
        • Ahokas A.
        • Albarran C.
        • et al.
        Agomelatine prevents relapse in generalized anxiety disorder: a 6-month randomized, double-blind, placebo-controlled discontinuation study.
        J Clin Psychiatry. 2012; 73: 1002-1008
        • Stein D.J.
        • Ahokas A.
        • Marquez M.S.
        • et al.
        Agomelatine in generalized anxiety disorder: an active comparator and placebo-controlled study.
        J Clin Psychiatry. 2014; 75: 362-368
        • Ripke S.
        • Wray N.R.
        • Lewis C.M.
        • et al.
        A mega-analysis of genome-wide association studies for major depressive disorder.
        Mol Psychiatry. 2013; 18: 497-511
        • Stoltenberg S.F.
        • Burmeister M.
        Recent progress in psychiatric genetics–some hope but no hype.
        Hum Mol Genet. 2000; 9: 927-935
        • Casey B.J.
        • Craddock N.
        • Cuthbert B.N.
        • et al.
        DSM-5 and RDoC: progress in psychiatry research?.
        Nat Rev Neurosci. 2013; 14: 810-814
        • Craddock N.
        • Owen M.J.
        The Kraepelinian dichotomy - going, going… but still not gone.
        Br J Psychiatry. 2010; 196: 92-95
        • Zhao X.
        • Yang Y.
        • Sun B.F.
        • et al.
        FTO and obesity: mechanisms of association.
        Curr Diab Rep. 2014; 14: 486
        • Albert F.W.
        • Kruglyak L.
        The role of regulatory variation in complex traits and disease.
        Nat Rev Genet. 2015; 16: 197-212
        • Etain B.
        • Milhiet V.
        • Bellivier F.
        • et al.
        Genetics of circadian rhythms and mood spectrum disorders.
        Eur Neuropsychopharmacol. 2011; 21: S676-S682
        • Pritchett D.
        • Wulff K.
        • Oliver P.L.
        • et al.
        Evaluating the links between schizophrenia and sleep and circadian rhythm disruption.
        J Neural Transm. 2012; 119: 1061-1075
        • Venter J.C.
        • Adams M.D.
        • Myers E.W.
        • et al.
        The sequence of the human genome.
        Science. 2001; 291: 1304-1351
      1. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
        Nat Genet. 2011; 43: 977-983
        • Ripke S.
        • O'Dushlaine C.
        • Chambert K.
        • et al.
        Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
        Nat Genet. 2013; 45: 1150-1159
        • Lee S.H.
        • Ripke S.
        • Neale B.M.
        • et al.
        Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.
        Nat Genet. 2013; 45: 984-994
        • McCarthy M.J.
        • Nievergelt C.M.
        • Kelsoe J.R.
        • et al.
        A survey of genomic studies supports association of circadian clock genes with bipolar disorder spectrum illnesses and lithium response.
        PLoS One. 2012; 7: e32091
        • Malhotra D.
        • Sebat J.
        CNVs: harbingers of a rare variant revolution in psychiatric genetics.
        Cell. 2012; 148: 1223-1241
        • Gershon E.S.
        • Alliey-Rodriguez N.
        • Liu C.
        After GWAS: searching for genetic risk for schizophrenia and bipolar disorder.
        Am J Psychiatry. 2011; 168: 253-256
        • Weaver I.C.
        Integrating early life experience, gene expression, brain development, and emergent phenotypes: unraveling the thread of nature via nurture.
        Adv Genet. 2014; 86: 277-307