Review Article| Volume 8, ISSUE 3, P373-387, September 2013

Insomnia and Cancer

Prevalence, Nature, and Nonpharmacologic Treatment

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      References

        • Savard J.
        • Morin C.M.
        Insomnia in the context of cancer: a review of a neglected problem.
        J Clin Oncol. 2001; 19: 895-908
        • Fiorentino L.
        • Ancoli-Israel S.
        Sleep dysfunction in patients with cancer.
        Curr Treat Options Neurol. 2007; 9: 337-346
        • Savard J.
        • Ancoli-Israel S.
        Sleep and fatigue in cancer patients.
        in: Kryger M.H. Roth T. Dement W.C. Principles and practice of sleep medicine. 5th edition. Elsevier Saunders, St Louis (MO)2011: 1416-1421
        • Fiorentino L.
        • Ancoli-Israel S.
        Insomnia and its treatment in women with breast cancer.
        Sleep Med Rev. 2006; 10: 419-429
        • Kvale E.A.
        • Shuster J.L.
        Sleep disturbance in supportive care of cancer: a review.
        J Palliat Med. 2006; 9: 437-450
        • Parish J.M.
        Sleep-related problems in common medical conditions.
        Chest. 2009; 135: 563-572
        • Berger A.M.
        Update on the state of the science: sleep-wake disturbances in adult patients with cancer.
        Oncol Nurs Forum. 2009; 36: E165-E177
        • Ancoli-Israel S.
        • Moores R.
        • Moores J.
        Recognition and treatment of sleep disturbances in cancer.
        J Clin Oncol. 2009; 27: 5864-5866
        • Savard J.
        • Villa J.
        • Ivers H.
        • et al.
        Prevalence, natural course, and risk factors of insomnia comorbid with cancer over a 2-month period.
        J Clin Oncol. 2009; 27: 5233-5239
        • Savard J.
        • Ivers H.
        • Villa J.
        • et al.
        Natural course of insomnia comorbid with cancer: an 18-month longitudinal study.
        J Clin Oncol. 2011; 29: 3580-3586
        • LeBlanc M.
        • Merette C.
        • Savard J.
        • et al.
        Incidence and risk factors of insomnia in a population-based sample.
        Sleep. 2009; 32: 1027-1037
        • Palesh O.G.
        • Roscoe J.A.
        • Mustian K.M.
        • et al.
        Prevalence, demographics, and psychological associations of sleep disruption in patients with cancer: University of Rochester Cancer Center-Community Clinical Oncology Program.
        J Clin Oncol. 2010; 28: 292-298
      1. Bernatchez MS, Savard J, Ivers H. Prevalence and evolution of insomnia among advanced cancer patients. 26th Annual Conference of the Canadian Association of Psychosocial Oncology. Toronto, May 2013.

        • Akechi T.
        • Okuyama T.
        • Akizuki N.
        • et al.
        Associated and predictive factors of sleep disturbance in advanced cancer patients.
        Psychooncology. 2007; 16: 888-894
        • Spielman A.J.
        • Glovinsky P.
        Case studies in insomnia.
        in: Hauri P.J. The varied nature of insomnia. Plenum Press, New York1991: 1-15
        • Davidson J.R.
        • MacLean A.W.
        • Brundage M.D.
        • et al.
        Sleep disturbance in cancer patients.
        Soc Sci Med. 2002; 54: 1309-1321
        • Palesh O.G.
        • Peppone L.
        • Innominato P.
        • et al.
        Prevalence, putative mechanisms and management of sleep problems during chemotherapy for cancer.
        Nat Sci Sleep. 2012; 4: 151-162
        • Desai K.
        • Mao J.J.
        • Su I.
        • et al.
        Prevalence and risk factors for insomnia among breast cancer patients on aromatase inhibitors.
        Support Care Cancer. 2013; 21: 43-51
        • Savard J.
        • Simard S.
        • Hervouet S.
        • et al.
        Insomnia in men treated with radical prostatectomy for prostate cancer.
        Psychooncology. 2005; 14: 147-156
        • Ginsburg M.L.
        • Quirt C.
        • Ginsburg A.D.
        • et al.
        Psychiatric illness and psychosocial concerns of patients with newly diagnosed lung cancer.
        CMAJ. 1995; 152: 701-709
        • Morin C.M.
        Insomnia: psychological assessment and management.
        The Guilford Press, New York1993
        • Van Onselen C.
        • Paul S.M.
        • Lee K.
        • et al.
        Trajectories of sleep disturbance and daytime sleepiness in women before and after surgery for breast cancer.
        J Pain Symptom Manage. 2013; 45: 244-260
        • Forsberg C.
        • Bjorvell H.
        • Cedermark B.
        Well-being and its relation to coping ability in patients with colo-rectal and gastric cancer before and after surgery.
        Scand J Caring Sci. 1996; 10: 35-44
        • Sheely L.C.
        Sleep disturbances in hospitalized patients with cancer.
        Oncol Nurs Forum. 1996; 23: 109-111
        • Enderlin C.A.
        • Coleman E.A.
        • Cole C.
        • et al.
        Sleep across chemotherapy treatment: a growing concern for women older than 50 with breast cancer.
        Oncol Nurs Forum. 2010; 37 (461–A3)
        • Beck S.L.
        • Berger A.M.
        • Barsevick A.M.
        • et al.
        Sleep quality after initial chemotherapy for breast cancer.
        Support Care Cancer. 2010; 18: 679-689
        • Chen M.L.
        • Yu C.T.
        • Yang C.H.
        Sleep disturbances and quality of life in lung cancer patients undergoing chemotherapy.
        Lung Cancer. 2008; 62: 391-400
        • Savard J.
        • Liu L.
        • Natarajan L.
        • et al.
        Breast cancer patients have progressively impaired sleep-wake activity rhythms during chemotherapy.
        Sleep. 2009; 32: 1155-1160
        • Cassileth P.A.
        • Lusk E.J.
        • Torri S.
        • et al.
        Antiemetic efficacy of dexamethasone therapy in patients receiving cancer chemotherapy.
        Arch Intern Med. 1983; 143: 1347-1349
        • Ling M.H.
        • Perry P.J.
        • Tsuang M.T.
        Side effects of corticosteroid therapy: psychiatric aspects.
        Arch Gen Psychiatry. 1981; 38: 471-477
        • Savard J.
        • Hervouet S.
        • Ivers H.
        Prostate cancer treatments and their side effects are associated with increased insomnia.
        Psychooncology. 2012 Aug 8; ([Epub ahead of print])https://doi.org/10.1002/pon.3150
        • Savard M.H.
        • Savard J.
        • Trudel-Fitzgerald C.
        • et al.
        Changes in hot flashes are associated with concurrent changes in insomnia symptoms among breast cancer patients.
        Menopause. 2011; 18: 985-993
        • Savard J.
        • Davidson J.R.
        • Ivers H.
        • et al.
        The association between nocturnal hot flashes and sleep in breast cancer survivors.
        J Pain Symptom Manage. 2004; 27: 513-522
        • Savard M.H.
        • Savard J.
        • Caplette-Gingras A.
        • et al.
        Relationship between objectively recorded hot flashes and sleep disturbances among breast cancer patients: investigating hot flash characteristics other than frequency.
        Menopause. 2013 Apr 29; ([Epub ahead of print])
        • Trudel-Fitzgerald C.
        • Savard J.
        • Ivers H.
        Which symptoms come first? Exploration of temporal relationships between cancer-related symptoms over an 18-month period.
        Ann Behav Med. 2013 Jun; 45: 329-337
        • Kamath J.
        Cancer-related fatigue, inflammation and thyrotropin-releasing hormone.
        Curr Aging Sci. 2012; 5: 195-202
        • Wood L.J.
        • Weymann K.
        Inflammation and neural signaling: etiologic mechanisms of the cancer treatment-related symptom cluster.
        Curr Opin Support Palliat Care. 2013; 7: 54-59
        • Belgrade M.J.
        Control of pain in cancer patients.
        Postgrad Med. 1989; 85: 319-329
        • Portenoy R.K.
        • Miransky J.
        • Thaler H.T.
        • et al.
        Pain in ambulatory patients with lung or colon cancer.
        Cancer. 1992; 70: 1616-1624
        • Taddeini L.
        • Rotschafer J.C.
        Pain syndromes associated with cancer.
        Postgrad Med. 1984; 75: 101-108
        • Buffum D.
        • Koetters T.
        • Cho M.
        • et al.
        The effects of pain, gender, and age on sleep/wake and circadian rhythm parameters in oncology patients at the initiation of radiation therapy.
        J Pain. 2011; 12: 390-400
        • Sharma N.
        • Hansen C.H.
        • O'Connor M.
        • et al.
        Sleep problems in cancer patients: prevalence and association with distress and pain.
        Psychooncology. 2013; 21: 1003-1009
        • Palesh O.G.
        • Collie K.
        • Batiuchok D.
        • et al.
        A longitudinal study of depression, pain, and stress as predictors of sleep disturbance among women with metastatic breast cancer.
        Biol Psychol. 2007; 75: 37-44
        • Zeitzer J.M.
        • Bliwise D.L.
        • Hernandez B.
        • et al.
        Nocturia compounds nocturnal wakefulness in older individuals with insomnia.
        J Clin Sleep Med. 2013; 9: 259-262
        • Hanisch L.J.
        • Gooneratne N.S.
        • Soin K.
        • et al.
        Sleep and daily functioning during androgen deprivation therapy for prostate cancer.
        Eur J Cancer Care. 2011; 20: 549-554
        • Ozturk A.
        • Sarihan S.
        • Ercan I.
        • et al.
        Evaluating quality of life and pulmonary function of long-term survivors of non-small cell lung cancer treated with radical or postoperative radiotherapy.
        Am J Clin Oncol. 2009; 32: 65-72
        • American Psychiatric Association
        Diagnostic and statistical manual of mental disorders, text revision.
        4th edition. American Psychiatric Association, Washington, DC2000
        • Breitbart W.
        • Cohen K.R.
        Delirium.
        in: Holland J.C. Psycho-oncology. Oxford University Press, New York1998: 564-575
        • Graydon J.E.
        • Bubela N.
        • Irvine D.
        • et al.
        Fatigue-reducing strategies used by patients receiving treatment for cancer.
        Cancer Nurs. 1995; 18: 23-28
        • Irvine D.M.
        • Vincent L.
        • Graydon J.E.
        • et al.
        Fatigue in women with breast cancer receiving radiation therapy.
        Cancer Nurs. 1998; 21: 127-135
        • Richardson A.
        • Ream E.K.
        Self-care behaviours initiated by chemotherapy patients in response to fatigue.
        Int J Nurs Stud. 1997; 34: 35-43
        • Howell D.
        • Oliver T.K.
        • Keller-Olaman S.
        • et al.
        A Pan-Canadian practice guideline: Prevention, screening, assessment, and treatment of sleep disturbances in adults with cancer.
        Supportive Care in Cancer. 2013 May 25; ([Epub ahead of print])
        • Langford D.J.
        • Lee K.
        • Miaskowski C.
        Sleep disturbance interventions in oncology patients and family caregivers: a comprehensive review and meta-analysis.
        Sleep Med Rev. 2012; 16: 397-414
        • Savard J.
        • Simard S.
        • Ivers H.
        • et al.
        Randomized study on the efficacy of cognitive-behavioral therapy for insomnia secondary to breast cancer, part I: sleep and psychological effects.
        J Clin Oncol. 2005; 23: 6083-6095
        • Espie C.A.
        • Fleming L.
        • Cassidy J.
        • et al.
        Randomized controlled clinical effectiveness trial of cognitive behavior therapy compared with treatment as usual for persistent insomnia in patients with cancer.
        J Clin Oncol. 2008; 26: 4651-4658
        • Berger A.M.
        • Kuhn B.R.
        • Farr L.A.
        • et al.
        One-year outcomes of a behavioral therapy intervention trial on sleep quality and cancer-related fatigue.
        J Clin Oncol. 2009; 27: 6033-6040
        • Davidson J.R.
        • Waisberg J.L.
        • Brundage M.D.
        • et al.
        Nonpharmacologic group treatment of insomnia: a preliminary study with cancer survivors.
        Psychooncology. 2001; 10: 389-397
        • Fiorentino L.
        • McQuaid J.R.
        • Liu L.
        • et al.
        Individual cognitive behavioral therapy for insomnia in breast cancer survivors: a randomized controlled crossover pilot study.
        Nat Sci Sleep. 2009; 2010: 1-8
        • Quesnel C.
        • Savard J.
        • Simard S.
        • et al.
        Efficacy of cognitive-behavioral therapy for insomnia in women treated for nonmetastatic breast cancer.
        J Consult Clin Psychol. 2003; 71: 189-200
        • Berger A.M.
        • VonEssen S.
        • Khun B.R.
        • et al.
        Feasibility of a sleep intervention during adjuvant breast cancer chemotherapy.
        Oncol Nurs Forum. 2002; 29: 1431-1441
        • Berger A.M.
        • Kuhn B.R.
        • Farr L.A.
        • et al.
        Behavioral therapy intervention trial to improve sleep quality and cancer-related fatigue.
        Psychooncology. 2009; 18: 634-646
        • Parker K.P.
        • Bliwise D.L.
        • Ribeiro M.
        • et al.
        Sleep/wake patterns of individuals with advanced cancer measured by ambulatory polysomnography.
        J Clin Oncol. 2008; 26: 2464-2472
        • Vena C.
        • Parker K.
        • Allen R.
        • et al.
        Sleep-wake disturbances and quality of life in patients with advanced lung cancer.
        Oncol Nurs Forum. 2006; 33: 761-769
        • Glare P.
        • Walsh D.
        • Sheehan D.
        The adverse effects of morphine: a prospective survey of common symptoms during repeated dosing for chronic cancer pain.
        Am J Hosp Palliat Care. 2006; 23: 229-235
        • McCurry S.M.
        • Pike K.C.
        • Vitiello M.V.
        • et al.
        Increasing walking and bright light exposure to improve sleep in community-dwelling persons with Alzheimer's disease: results of a randomized, controlled trial.
        J Am Geriatr Soc. 2011; 59: 1393-1402
        • McCurry S.M.
        • Gibbons L.E.
        • Logsdon R.G.
        • et al.
        Nighttime insomnia treatment and education for Alzheimer's disease: a randomized, controlled trial.
        J Am Geriatr Soc. 2005; 53: 793-802
        • Alessi C.A.
        • Martin J.L.
        • Webber A.P.
        • et al.
        Randomized, controlled trial of a nonpharmacological intervention to improve abnormal sleep/wake patterns in nursing home residents.
        J Am Geriatr Soc. 2005; 53: 803-810
        • Simeit R.
        • Deck R.
        • Conta-Marx B.
        Sleep management training for cancer patients with insomnia.
        Support Care Cancer. 2004; 12: 176-183
        • Mann E.
        • Smith M.J.
        • Hellier J.
        • et al.
        Cognitive behavioural treatment for women who have menopausal symptoms after breast cancer treatment (MENOS 1): a randomised controlled trial.
        Lancet Oncol. 2012; 13: 309-318
        • Casault L.
        • Savard J.
        • Ivers H.
        • et al.
        Utilization of hypnotic medication in the context of cancer: predictors and frequency of use.
        Support Care Cancer. 2012; 20: 1203-1210
        • van Straten A.
        • Cuijpers P.
        Self-help therapy for insomnia: a meta-analysis.
        Sleep Med Rev. 2009; 13: 61-71
        • Savard J.
        • Villa J.
        • Simard S.
        • et al.
        Feasibility of a self-help treatment for insomnia comorbid with cancer.
        Psychooncology. 2011; 20: 1013-1019
        • Ritterband L.M.
        • Bailey E.T.
        • Thorndike F.P.
        • et al.
        Initial evaluation of an internet intervention to improve the sleep of cancer survivors with insomnia.
        Psychooncology. 2012; 21: 695-705
      2. Savard J, Ivers H, Savard MH, et al. Is a video-based cognitive-behavioral therapy as efficacious as a professionally-administered treatment for insomnia comorbid with cancer? Preliminary results of a randomized controlled trial, 10th conference of the American Psychosocial Oncology Society. Huntington Beach (CA): 2013.

        • Espie C.A.
        Stepped care: a health technology solution for delivering cognitive behavioral therapy as a first line insomnia treatment.
        Sleep. 2009; 32: 1549-1558
        • Newman M.G.
        Recommendations for a cost-offset model of psychotherapy allocation using generalized anxiety disorder as an example.
        J Consult Clin Psychol. 2000; 68: 549-555
        • Haaga D.A.
        Introduction to the special section on stepped care models in psychotherapy.
        J Consult Clin Psychol. 2000; 68: 547-548
        • Payne J.K.
        • Held J.
        • Thorpe J.
        • et al.
        Effect of exercise on biomarkers, fatigue, sleep disturbances, and depressive symptoms in older women with breast cancer receiving hormonal therapy.
        Oncol Nurs Forum. 2008; 35: 635-642
        • Tang M.F.
        • Liou T.H.
        • Lin C.C.
        Improving sleep quality for cancer patients: benefits of a home-based exercise intervention.
        Support Care Cancer. 2010; 18: 1329-1339
        • Wang Y.J.
        • Boehmke M.
        • Wu Y.W.
        • et al.
        Effects of a 6-week walking program on Taiwanese women newly diagnosed with early-stage breast cancer.
        Cancer Nurs. 2011; 34: E1-E13
        • Courneya K.S.
        • Sellar C.M.
        • Trinh L.
        • et al.
        A randomized trial of aerobic exercise and sleep quality in lymphoma patients receiving chemotherapy or no treatments.
        Cancer Epidemiol Biomarkers Prev. 2012; 21: 887-894
        • Dodd M.J.
        • Cho M.H.
        • Miaskowski C.
        • et al.
        A randomized controlled trial of home-based exercise for cancer-related fatigue in women during and after chemotherapy with or without radiation therapy.
        Cancer Nurs. 2010; 33: 245-257
        • Andersen S.R.
        • Wurtzen H.
        • Steding-Jessen M.
        • et al.
        Effect of mindfulness-based stress reduction on sleep quality: results of a randomized trial among Danish breast cancer patients.
        Acta Oncol. 2013; 52: 336-344
        • Carson J.W.
        • Carson K.M.
        • Porter L.S.
        • et al.
        Yoga of Awareness program for menopausal symptoms in breast cancer survivors: results from a randomized trial.
        Support Care Cancer. 2009; 17: 1301-1309
        • Cohen L.
        • Warneke C.
        • Fouladi R.T.
        • et al.
        Psychological adjustment and sleep quality in a randomized trial of the effects of a Tibetan yoga intervention in patients with lymphoma.
        Cancer. 2004; 100: 2253-2260
        • Buffart L.M.
        • van Uffelen J.G.
        • Riphagen I.I.
        • et al.
        Physical and psychosocial benefits of yoga in cancer patients and survivors, a systematic review and meta-analysis of randomized controlled trials.
        BMC Cancer. 2012; 12: 559-580
        • Esptein D.R.
        • Dirksen S.R.
        Randomized trial of a cognitive-behavioral intervention for insomnia in breast cancer survivors.
        Oncology Nursing Forum. 2007; 34 (E51–9)