Multiple Sleep Latency Test and Maintenance of Wakefulness Test

      Degrees of excessive daytime sleepiness can be quantified by obtaining a comprehensive history in conjunction with various diagnostic studies, such as an overnight polysomnography, the multiple sleep latency test, and the maintenance of wakefulness test. Although the multiple sleep latency test and maintenance of wakefulness test are laboratory-based assessments of sleepiness and wakefulness, respectively, these findings on these tests may not always correlate with patient safety in the workplace or while driving. Further research is needed to improve the diagnostic accuracy of our assessments of excessive daytime sleepiness.


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        • Littner M.R.
        • Kushida C.
        • Wise M.
        • et al.
        Practice parameters for clinical use of the multiple sleep latency test and the maintenance of wakefulness test.
        Sleep. 2005; 28: 113-121
        • Johns M.W.
        Reliability and factor analysis of the Epworth Sleepiness Scale.
        Sleep. 1992; 15: 376-381
        • Weaver T.E.
        • Laizner A.M.
        • Evans L.K.
        • et al.
        An instrument to measure functional status outcomes for disorders of excessive sleepiness.
        Sleep. 1997; 20: 835-843
        • Carskadon M.A.
        • Dement W.C.
        • Mitler M.M.
        • et al.
        Guidelines for the multiple sleep latency test (MSLT): a standard measure of sleepiness.
        Sleep. 1986; 9: 519-524
        • Silber M.H.
        • Ancoli-Israel S.
        • Bonnet M.H.
        • et al.
        The visual scoring of sleep in adults.
        J Clin Sleep Med. 2007; 3: 121-131
        • Thorpy M.
        • Westbrook P.
        • Ferber R.
        • et al.
        The clinical use of the multiple sleep latency test.
        Sleep. 1992; 15: 268-276
        • Chervin R.D.
        • Aldrich M.S.
        Sleep onset REM periods during multiple sleep latency tests in patients evaluated for sleep apnea.
        Am J Respir Crit Care Med. 2000; 161: 426-431
        • Doghramji K.
        • Mitler M.M.
        • Sangal R.B.
        • et al.
        A normative study of the maintenance of wakefulness test.
        Electroencephalogr Clin Neurophysiol. 1997; 103: 554-562
        • Mitler M.M.
        • Doghramji K.
        • Shapiro C.
        The maintenance of wakefulness test: normative data by age.
        J Psychosom Res. 2000; 49: 363-365
        • Poceta J.S.
        • Timms R.M.
        • Jeong D.U.
        • et al.
        Maintenance of wakefulness test in obstructive sleep apnea syndrome.
        Chest. 1992; 101: 893-897
        • Office of Aerospace Medicine
        Guide for aviation medical examiners.
        (Available at:) (Accessed Febrauary 1, 2009)
        • Wise M.S.
        • Arand D.L.
        • Auger R.R.
        • et al.
        Treatment of narcolepsy and other hypersomnias of central origin.
        Sleep. 2007; 30: 1712-1727
      1. (Available at:) (Accessed February 1, 2009)
        • Bennett L.S.
        • Stradling J.R.
        • Davies R.J.O.
        A behavioural test to assess daytime sleepiness in obstructive sleep apnea.
        J Sleep Res. 1997; 6: 142-145
        • Wilhelm B.
        • Wilhelm H.
        • Ludtke H.
        • et al.
        Pupillometric assessment of sleepiness in sleep-deprived healthy subjects.
        Sleep. 1998; 21: 258-265