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Sleep Deprivation and Sleepiness Caused by Sleep Loss

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      References

        • Lyznicki J.M.
        • Doege T.C.
        • Davis R.M.
        • et al.
        Sleepiness, driving, and motor vehicle crashes.
        JAMA. 1998; 279: 1908-1913
        • Kushida C.
        Sleep deprivation: basic science, physiology, and behavior.
        Lung Biology in Health and Disease. 2005; 192: 1-46
        • Kushida C.
        Sleep deprivation: clinical issues, pharmacology, and sleep loss effects.
        Lung Biology in Health and Disease. 2005; 193: 195-385
        • Farooqui S.M.
        • Brock J.W.
        • Zhou J.
        Changes in monoamines and their metabolite concentrations in REM sleep-deprived rat forebrain nuclei.
        Pharmacol Biochem Behav. 1996; 54: 385-391
        • Frussa-Filho R.
        • Gonçalves M.T.M.
        • Andersen M.L.
        • et al.
        Paradoxical sleep deprivation potentiates amphetamine-induced behavioural sensitization by increasing its conditioned component.
        Brain Res. 2004; 1003: 188-193
        • Andersen M.L.
        • Perry J.C.
        • Tufik S.
        Acute cocaine effects in paradoxical sleep deprived male rats.
        Prog Neuropsychopharmacol Biol Psychiatry. 2005; 29: 245-251
        • Jouvet D.
        • Vilmont P.
        • Delorme F.
        • et al.
        Etude de la privation sélective de la phase paradoxale de sommeil chez le chat.
        Compt Rend Soc Biol. 1964; 158: 756-759
        • Cohen H.B.
        • Dement W.C.
        Sleep: changes in threshold to electroconvulsive shock in rats after deprivation of paradoxical phase.
        Science. 1965; 150: 1318-1319
        • Van Hulzen Z.J.M.
        • Coenen A.M.L.
        Paradoxical sleep deprivation and locomotor activity in rats.
        Physiol Behav. 1981; 27: 741-744
        • Nunes G.P.
        • Tufik S.
        Validation of the modified multiple platform method (MMP) of paradoxical sleep deprivation in rats.
        Sleep Res. 1994; 22: 419
        • Tufik S.
        • Lindsey C.J.
        • Carlini E.A.
        Does REM sleep deprivation induce a supersensitivity of dopaminergic receptors in the rat brain?.
        Pharmacology. 1978; 16: 95-108
        • Nunes G.P.
        • Tufik S.
        • Nobrega J.N.
        Autoradiographic analysis of D1 and D2 dopaminergic receptors in rat brain after paradoxical sleep deprivation.
        Brain Res Bull. 1994; 34: 435-456
        • Easton A.
        • Meerlo P.
        • Bergmann B.
        • et al.
        The suprachiasmatic nucleus regulates sleep timing and amount in mice.
        Sleep. 2004; 27: 1307-1318
        • Ledoux L.
        • Sastre J.P.
        • Buda C.
        • et al.
        Alterations in c-fos expression after different experimental procedures of sleep deprivation in the cat.
        Brain Res. 1996; 735: 108-118
        • Cirelli C.
        How sleep deprivation affects gene expression in the brain: a review of recent findings.
        J Appl Physiol. 2002; 92: 394-400
        • Naidoo N.
        • Giang W.
        • Galante R.J.
        • et al.
        Sleep deprivation induces the unfolded protein response in mouse cerebral cortex.
        J Neurochem. 2005; 92: 1150-1157
        • Andersen M.L.
        • Martins P.J.F.
        • D'Almeida V.
        • et al.
        Endocrinological alterations during sleep deprivation and recovery in male rats.
        J Sleep Res. 2005; 14: 83-90
        • Cauter E.V.
        Sleep loss, jet lag, and shift work.
        in: Fink G. Encyclopedia of stress. vol. 1. Academic Press, San Diego2000: 447-448
        • Meerlo P.
        • Koehl M.
        • van der Borght K.
        • et al.
        Sleep restriction alters the hypothalamic-pituitary-adrenal response to stress.
        J Neuroendocrinol. 2002; 14: 397-402
        • Rechtschaffen A.
        • Bergmann B.M.
        • Everson C.A.
        Sleep deprivation in the rat: III. Total sleep deprivation.
        Sleep. 1989; 12: 1-4
        • Everson C.A.
        • Laatsch C.D.
        • Hogg N.
        Antioxidant defense responses to sleep loss and sleep recovery.
        Am J Physiol Regul Integr Comp Physiol. 2005; 288: R374-R383
        • Inoue S.
        • Honda K.
        • Komoda Y.
        Sleep as neuronal detoxification and restitution.
        Behav Brain Res. 1995; 69: 91-96
        • Benedetti F.
        • Serretti A.
        • Colombo C.
        • et al.
        Dopamine receptor D2 and D3 gene variants are not associated with the antidepressant effect of total sleep deprivation in bipolar depression.
        Psychol Res. 2003; 118: 241-247
        • Ebert D.
        • Albert R.
        • Hammon G.
        • et al.
        Eye blink rate and depression. Is the antidepressant effect of sleep deprivation mediated by the dopamine system?.
        Neuropsychopharmacol. 1996; 15: 332-339
        • Andersen M.L.
        • Bignotto M.
        • Tufik S.
        Influence of paradoxical sleep deprivation and cocaine on development of spontaneous penile reflexes in rats of different ages.
        Brain Res. 2003; 968: 130-138
        • Andersen M.L.
        • Bignotto M.
        • Tufik S.
        Hormone treatment facilitates penile erection in castrated rats after sleep deprivation and cocaine.
        J Neuroendocrinol. 2004; 16: 154-159
        • Harrison Y.
        • Horne J.A.
        Sleep loss impairs short and novel language tasks having a prefrontal focus.
        J Sleep Res. 1998; 7: 95-100
        • Mu G.
        • Nahas Z.
        • Johnson K.A.
        • et al.
        Decreased cortical response to verbal working memory following sleep deprivation.
        Sleep. 2005; 28: 55-67
        • Vgontzas A.N.
        • Zoumakis E.
        • Bixler E.O.
        • et al.
        Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines.
        J Clin Endocrinol Metab. 2004; 89: 2119-2126
        • De Valck E.
        • Cluydts R.
        • Pirrera S.
        Effect of cognitive arousal on sleep latency, somatic and cortical arousal following partial sleep deprivation.
        J Sleep Res. 2004; 13: 295-304
        • Walker M.P.
        • Stickgold R.
        Sleep-dependent learning and memory consolidation.
        Neuron. 2004; 44: 121-133
        • Romcy-Pereira R.
        • Pavlides C.
        Distinct modulatory effects of sleep on the maintenance of hippocampal and medial prefrontal cortex LTP.
        Eur J Neurosci. 2004; 20: 3453-3462
        • Bueno O.F.A.
        • Lobo L.L.
        • Oliveira M.G.M.
        • et al.
        Dissociated paradoxical sleep deprivation effects on inhibitory avoidance and conditioned fear.
        Physiol Behav. 1994; 56: 775-779
        • Silva R.H.
        • Abílio V.C.
        • Takatsu A.L.
        • et al.
        Role of hippocampal oxidative stress in memory deficits induced by sleep deprivation in mice.
        Neuropharmacology. 2004; 46: 895-903
        • Bonnet M.H.
        • Arand D.L.
        Clinical effects of sleep fragmentation versus sleep deprivation.
        Sleep Med Rev. 2003; 7: 293-295
        • Persson H.E.
        • Svanborg E.
        Sleep deprivation worsens obstructive sleep apnea: comparison between diurnal and nocturnal polysomnography.
        Chest. 1996; 109: 645-650
        • Santos H.E.R.
        • De Mello M.T.
        • Pradella-Hallinan M.
        • et al.
        Sep and sleepiness among Brazilian shift-work bus drivers.
        Chronobiol Int. 2004; 21: 881-888
        • Vorona R.D.
        • Winn M.P.
        • Babineau T.W.
        • et al.
        Overweight and obese patients in a primary care population report less sleep than patients with a normal body mass index.
        Arch Intern Med. 2005; 165: 15-16
        • Everson C.A.
        • Bergmann B.M.
        • Rechtschaffen A.
        Sleep deprivation in the rat: II. Total sleep deprivation.
        Sleep. 1989; 12: 13-21
        • Spiegel K.
        • Tasali E.
        • Penev P.
        • et al.
        Brief communication: sep curtailment in health young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite.
        Ann Intern Med. 2004; 7: 141-152
        • Irwin M.
        Effects of sleep and sleep loss on immunity and cytokines.
        Behav Brain Immun. 2002; 16: 503-512
        • Meier-Ewert H.K.
        • Ridker P.M.
        • Rifai N.
        • et al.
        Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk.
        J Am Coll Cardiol. 2004; 44: 1529-1530
        • Beersma D.G.
        Models of human sleep regulation.
        Sleep Med Rev. 1998; 2: 31-43
        • Rosenthal L.
        • Roehrs T.A.
        • Rosen A.
        • et al.
        Level of sleepiness and total sleep time following various time in bed conditions.
        Sleep. 1993; 16: 226-232
        • Carskadon M.A.
        • Dement W.C.
        Cumulative effects of sleep restriction on daytime sleepiness.
        Psychophysiology. 1981; 18: 107-113
        • Chugh D.K.
        • Weaver T.E.
        • Dinges D.F.
        Neurobehavioral consequences of arousals.
        Sleep. 1996; 19: S198-S201
        • Philip P.
        • Stoohs R.
        • Guilleminault C.
        Sleep fragmentation in normals.
        Sleep. 1994; 17: 242-247
        • Carskadon M.A.
        • Dement W.C.
        Effects of total sleep loss on sleep tendency.
        Percept Mot Skills. 1979; 48: 495-506
        • Chervin R.D.
        • Kraemer H.C.
        • Guilleminault C.
        Correlates of sleep latency on the multiple sleep latency test in a clinical population.
        Electroencephalogr Clin Neurophysiol. 1995; 95: 147-153
        • Richardson G.S.
        • Carskadon M.A.
        • Flagg W.
        • et al.
        Excessive daytime sleepiness in man: multiple sleep latency measurement in narcoleptic and control subjects.
        Electroencephalogr Clin Neurophysiol. 1978; 45: 621-627
        • Amira S.A.
        • Johnson T.S.
        • Logowitz N.B.
        Diagnosis of narcolepsy using the multiple sleep latency test: analysis of current laboratory criteria.
        Sleep. 1985; 8: 325-331
        • Aldrich M.S.
        • Chervin R.D.
        • Malow B.A.
        Value of the multiple sleep latency test (MSLT) for the diagnosis of narcolepsy.
        Sleep. 1997; 20: 620-629
        • Carskadon M.A.
        • Dement W.C.
        Sleep loss in elderly volunteers.
        Sleep. 1985; 83: 207-221
        • Van den Hoed J.
        • Kraemer H.
        • Guilleminault C.
        • et al.
        Disorders of excessive daytime somnolence: polygraphic and clinical data for 100 patients.
        Sleep. 1981; 4: 23-27
        • Mitler M.M.
        • Gujavarty K.S.
        • Browman C.P.
        Maintenance of wakefulness test: a polysomnographic technique for evaluation treatment efficacy in patients with excessive somnolence.
        Electroencephalogr Clin Neurophysiol. 1982; 53: 658-661
      1. Mitler M.M. Maintenance of Wakefulness Test (MWT). In: Kushida C.A., editor. Sleep deprivation: Clinical issues, pharmacology and sleep loss effects. Lung Biology in Health and Disease 2005;193:325–8

        • US Modafinil in Narcolepsy Multicenter Study Group
        Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy.
        Ann Neurol. 1998; 43: 88-97
        • Sangal R.B.
        • Thomas L.
        • Mitler M.M.
        Disorders of excessive sleepiness: treatment improves ability to stay awake but does not reduce sleepiness.
        Chest. 1992; 102: 699-703
        • Sangal R.B.
        • Thomas L.
        • Mitler M.M.
        Maintenance of wakefulness test and multiple sleep latency test: measurement of different abilities in patients with sleep disorders [see comments].
        Chest. 1992; 101: 898-902
        • Dinges D.F.
        • Pack F.
        • Williams K.
        • et al.
        Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4–5 hours per night.
        Sleep. 1997; 20: 267-277
        • Jewett M.E.
        • Dijk D.J.
        • Kronauer R.E.
        • et al.
        Dose-response relationship between sleep duration and human psychomotor vigilance and subjective alertness.
        Sleep. 1999; 22: 171-179
        • Kribbs N.B.
        • Dinges D.F.
        Vigilance decrement and sleepiness.
        in: Harsh J.R. Ogilvie R.D. Sleep onset mechanisms. American Psychological Association, Washington1994: 113-125
        • Van Dongen H.P.A.
        • Dinges D.F.
        Circadian rhythms in fatigue, alertness and performance.
        in: Kryger M.H. Roth T. Dement W.C. Principles and practice of sleep medicine. WB Saunders, Philadelphia2000: 391-399
        • Dinges D.F.
        • Weaver T.
        Effects of modafinil on sustained attention performance and quality of life in OSA patients with residual sleepiness while being treated with nCPAP.
        Sleep Med. 2003; 4: 393-402
        • Seidel W.F.
        • Balls S.
        • Cohen S.
        • et al.
        Daytime alertness in relation to mood, performance and nocturnal sleep in chronic insomniacs and noncomplaining sleepers.
        Sleep. 1984; 7: 230-238
        • Pressman M.R.
        • Fry J.M.
        Relationship of autonomic nervous system activity to daytime sleepiness and prior sleep.
        Sleep. 1989; 12: 239-245
        • Hoch C.C.
        • Reynolds C.F.
        • Jennings R.
        • et al.
        Daytime sleepiness and performance among healthy 80 and 20 year olds.
        Neurobiol Aging. 1991; 13: 353-356
        • Harnish M.J.
        • Chard S.R.
        • Orr W.C.
        Relationship between measures of objective and subjective sleepiness.
        Sleep Res. 1996; 25: 492
        • Hoddes E.
        • Dement W.C.
        • Zarcone V.
        The development and use of the Stanford Sleepiness Scale (SSS).
        Psychophysiology. 1972; 1: 150-157
        • Herscovitch J.
        • Broughton R.
        Sensitivity of the Stanford Sleepiness Scale to the effects of cumulative sleep deprivation and recovery oversleeping.
        Sleep. 1981; 4: 83-92
        • Johns M.W.
        A new method of sleepiness: the Epworth sleepiness scale.
        Sleep. 1991; 14: 540-545
        • Sangal R.B.
        • Sangal J.M.
        • Belisle C.
        MWT and ESS measure different abilities in 41 patients with snoring and daytime sleepiness.
        Sleep Res. 1997; 26: 493
        • Chervin R.
        • Aldrich M.S.
        • Pickett R.
        • et al.
        Comparison of the results of Epworth Sleepiness Scale and multiple sleep latency test.
        J Psychosom Res. 1997; 42: 145-155
        • Rosenthal L.
        • Roehr T.A.
        • Roth T.
        The sleep-wake activity inventory: a self-report measure of daytime sleepiness.
        Biol Psychiatry. 1993; 34: 810-820
      2. Sleep in America poll. National Sleep Foundation, 2005 (Available at:) (Accessed January 12, 2006)
        • Engleman H.M.
        • Kingshott R.N.
        • Martin S.E.
        • et al.
        Cognitive function in the sleep apnea/hypopnea syndrome (SAHS).
        Sleep. 2000; 23: S102-S108
        • Spielman A.
        • Caruso L.
        • Glovinsk P.
        A behavioral perspective on insomnia treatment.
        Psychiatry Clin North Am. 1987; 10: 541-553
        • American Academy of Sleep Medicine
        The international classification of sleep disorders. 2nd edition. Diagnostic and coding manual. American Academy of Sleep Medicine, Westchester (IL)2005
        • Vgontzas A.N.
        • Bixler E.O.
        • Kales A.
        • et al.
        Validity and clinical utility of sleep laboratory criteria for insomnia.
        Int J Neurosci. 1994; 77: 11-21
        • Bonnet M.H.
        • Arand D.L.
        Clinical effects of sleep fragmentation versus sleep deprivation.
        Sleep Med Rev. 2003; 7: 297-310
        • Guilleminault C.
        • Stoohs R.
        • Clerk A.
        • et al.
        A cause of excessive daytime sleepiness: the upper airway resistance syndrome.
        Chest. 1993; 104: 781-787
        • Guilleminault C.
        • Black J.E.
        • Palombini L.
        • et al.
        A clinical investigation of obstructive sleep apnea syndrome (OSAS) and upper airway resistance syndrome (UARS) patients.
        Sleep Med. 2000; 1: 51-56
        • Halasz P.
        • Terzano M.
        • Parrino L.
        • et al.
        The nature of arousal in sleep.
        J Sleep Res. 2004; 13: 1-23
        • Czeisler C.A.
        • Richardson G.S.
        Detection and assessment of insomnia.
        Clin Ther. 1991; 13: 663-679
        • Kales A.
        • Kales J.D.
        Evaluation and treatment of insomnia. Oxford University Press, New York1984
        • Ford D.E.
        • Kamerow D.B.
        Epidemiologic study of sleep disturbances and psychiatric disorders.
        JAMA. 1989; 262: 1479-1484
        • Postolache T.T.
        • Oren D.A.
        Circadian phase shifting, alerting, and antidepressant effects of bright light treatment.
        Clin Sports Med. 2005; 24: 381-413
        • Borbely A.A.
        A two process model of sleep regulation.
        Hum Neurobiol. 1982; 1: 195-204
        • Morin C.M.
        • Hauri P.J.
        • Espie C.A.
        • et al.
        Nonpharmacologic treatment of chronic insomnia.
        Sleep. 1999; 22: 1134-1156
        • Spielman A.J.
        • Yang C.M.
        • Glovinsky P.B.
        Assessment techniques for insomnia.
        in: Kriger M.K. Ruth T. Dement W.C. Principles and practice of sleep medicine. 3rd edition. WB Saunders, Philadelphia2000: 1239-1250
        • National Institutes of Health
        Drugs and insomnia: the use of medication to promote sleep.
        JAMA. 1984; 18: 2410-2414
        • National Institutes of Health
        Consensus development conference statement: the treatment of sleep disorders of older people.
        Sleep. 1991; 14: 169-177
        • Bonnet M.H.
        • Arand D.L.
        The consequences of a week of insomnia.
        Sleep. 1996; 19: 453-461
        • Nofzinger E.A.
        • Buysse D.J.
        • Germain A.
        • et al.
        Functional neuroimaging evidence for hyperarousal in insomnia.
        Am J Psychiatry. 2004; 161: 2126-2128
        • Spiegel K.
        • Tasali E.
        • Penev P.
        • et al.
        Brief communication: sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite.
        Ann Intern Med. 2004; 141: 846-850
        • Monk T.H.
        Shift work.
        in: Kryger M.H. Roth T. Dement W.C. Principles and practices of sleep medicine. 3rd edition. WB Saunders, Philadelphia2000: 602-603
        • Akerstedt T.
        Sleepiness as a consequence of shift work.
        Sleep. 1988; 11: 17-34
        • Budnick L.D.
        • Lerman S.E.
        • Baker T.L.
        • et al.
        Sleep and alertness in a 12-hour rotating shift work environment.
        J Occup Med. 1994; 36: 1295-1300
        • Chesson Jr, A.L.
        • Littner M.
        • Davila D.
        • et al.
        Practice parameters for the use of light therapy in the treatment of sleep disorders. Standards of Practice Committee, American Academy of Sleep Medicine.
        Sleep. 1999; 22: 641-660
        • Skene D.J.
        Optimization of light and melatonin to phase-shift human circadian rhythms.
        J Neuroendocrinol. 2003; 15: 438-441
        • Arendt J.
        • Skene D.J.
        • Middleton B.
        • et al.
        Efficacy of melatonin treatment in jet lag, shift work, and blindness.
        J Biol Rhythms. 1997; 12: 604-617
        • Waterhouse J.
        • Reilly T.
        • Edwards B.
        The stress of travel.
        J Sports Sci. 2004; 22: 946-965
        • Philip P.
        • Stoohs R.
        • Guilleminault C.
        Sleep fragmentation in normals.
        Sleep. 1994; 17: 242-247
        • Chugh D.K.
        • Weaver T.E.
        • Dinges D.F.
        Neurobehavioral consequences of arousals.
        Sleep. 1996; 19: S198-S201
        • Melendres C.S.
        • Lutz J.M.
        • Rubin E.D.
        • et al.
        Daytime sleepiness and hyperactivity in children with suspected sleep-disordered breathing.
        Pediatrics. 2004; 114: 768-775
        • Golan N.
        • Shahar E.
        • Ravid S.
        • et al.
        Sleep disorders and daytime sleepiness in children with attention-deficit/hyperactive disorder.
        Sleep. 2004; 27: 261-266
        • Gozal D.
        • Wang M.
        • Pope D.W.
        Objective sleepiness measure in pediatric obstructive sleep apnea.
        Pediatrics. 2001; 108: 693-697
        • Rosen C.L.
        • Storfer-Isser A.
        • Taylor H.G.
        • et al.
        Increased behavioral morbidity in school-aged children with sleep-disordered breathing.
        Pediatrics. 2004; 114: 1640-1648
        • Chervin R.D.
        • Archbold K.H.
        • Dillon J.E.
        • et al.
        Inattention, hyperactivity, and symptoms of sleep-disordered breathing.
        Pediatrics. 2002; 109: 449-456
        • O'Brien L.M.
        • Mervis C.B.
        • Holbrook C.R.
        • et al.
        Neurobehavioral implications of habitual snoring in children.
        Pediatrics. 2004; 114: 44-49
        • Picchietti D.L.
        • England S.J.
        • Walters A.S.
        • et al.
        Periodic limb movements disorder and restless legs syndrome in children with attention-deficit hyperactivity disorder.
        J Child Neurol. 1998; 13: 588-594
        • Picchietti D.L.
        • Walters A.S.
        Moderate to severe periodic limb movements disorder in childhood and adolescence.
        Sleep. 1999; 22: 297-300
        • Young T.
        • Peppard P.E.
        • Gottlieb D.J.
        Epidemiology of obstructive sleep apnea: a population health perspective.
        Am J Respir Crit Care Med. 2002; 165: 1217-1239
        • Ali N.J.
        • Pitson D.J.
        • Stradling J.R.
        Snoring, sleep disturbance, and behaviour in 4–5 year olds.
        Arch Dis Child. 1993; 68: 360-366
        • Castronovo V.
        • Zucconi M.
        • Nosetti L.
        • et al.
        Prevalence of habitual snoring and sleep-disordered breathing in preschool-aged children in an Italian community.
        J Pediatr. 2003; 142: 377-382
        • Redline S.
        • Tishler P.V.
        • Schluchter M.
        • et al.
        Risk factors for sleep-disordered breathing in children: associations with obesity, race, and respiratory problems.
        Am J Respir Crit Care Med. 1999; 159: 1527-1532
        • Guilleminault C.
        • Tilkian A.
        • Dement W.C.
        The sleep apnea syndromes.
        Annu Rev Med. 1976; 27: 465-484
        • Bassiri A.G.
        • Guilleminault C.
        Clinical features of evaluation of obstructive sleep apnea-hypopnea syndrome.
        in: Kryger M.H. Roth T. Dement W.C. Principles and practices of sleep medicine. 3rd edition. WB Saunders, Philadelphia2000: 868-878
        • Guilleminault C.
        • Do Kim Y.
        • Chowdhuri S.
        • et al.
        Sleep and daytime sleepiness in upper airway resistance syndrome compared to obstructive sleep apnoea syndrome.
        Eur Respir J. 2001; 17: 838-847
        • Chervin R.D.
        Sleepiness, fatigue, tiredness, and lack of energy in obstructive sleep apnea.
        Chest. 2000; 118: 372-379
        • Gastaut H.
        • Tassinari C.A.
        • Duron B.
        Polygraphic study of the episodic diurnal and nocturnal (hypnic and respiratory) manifestations of the Pickwick syndrome.
        Brain Res. 1966; 1: 167-186
        • Guilleminault C.
        • van den Hoed J.
        • Mitler M.
        Clinical overview of the sleep apnea syndromes.
        in: Guillemininault C. Dement W. Sleep apnea syndromes. Alan R Liss, New York1978: 1-11
        • Bradley T.D.
        • McNicholas W.T.
        • Rutherford R.
        • et al.
        Clinical physiological heterogeneity of the central sleep apnea syndrome.
        Am Rev Respir Crit Care Med. 1986; 134: 217-221
        • Findley L.J.
        • Zwillich C.W.
        • Ancoli-Israel S.
        • et al.
        Cheyne-Stokes breathing during sleep in patients with left ventricular heart failure.
        South Med J. 1985; 78: 11-15
        • Chesson A.L.
        • Wise M.
        • Davila D.
        • et al.
        Practice parameters for the treatment of restless legs syndrome and periodic limb movement disorder.
        Sleep. 1999; 22: 961-968
        • American Academy of Sleep Medicine
        Sleep related movement disorders.
        in: The international classification of sleep disorders. Diagnostic and coding manual. 2nd edition. American Academy of Sleep Medicine, Westchester (IL)2005
        • Ohayon M.M.
        • Roth T.
        Prevalence of restless legs syndrome and periodic limb movement disorder in the general population.
        J Psychosom Res. 2002; 53: 547-554
        • Kirk V.G.
        • Bohn S.
        Periodic limb movements in children: prevalence in a referred population.
        Sleep. 2004; 27: 313-315
        • American Sleep Disorders Association
        International classification of sleep disorders, revised: diagnostic and coding manual. American Sleep Disorders Association, Rochester (MN)1997
        • Mendelson W.B.
        Are periodic leg movements associated with clinical sleep disturbance?.
        Sleep. 1996; 19: 219-223
        • Chervin R.D.
        Periodic limb movements and sleepiness in patients evaluated for sleep-disordered breathing.
        Am J Respir Crit Care Med. 2001; 164: 1454-1458
        • Askenasy J.J.M.
        Sleep in Parkinson's disease.
        Acta Neurol Scand. 1993; 87: 167-170
        • Chokroverty S.
        Sleep and degenerative neurologic disorders.
        Neurol Clin. 1996; 14: 807-826
        • Trenkwalder C.
        Sleep dysfunction in Parkinson's disease.
        Clin Neurosci. 1998; 5: 107-114
        • George C.F.P.
        Neuromuscular disorders.
        in: Kryger M.H. Roth T. Dement W.C. Principles and practice of sleep medicine. 3rd edition. WB Saunders, Philadelphia2000: 1087-1092
        • Gibbs J.W.
        • Ciafaloni E.
        • Radtke R.A.
        Excessive daytime somnolence and increased rapid eye movement pressure in myotonic dystrophy.
        Sleep. 2002; 25: 662-665
        • Campbell S.M.
        • Clark S.
        • Tindall E.A.
        • et al.
        Clinical characteristics of fibrositis. I: A blinded controlled study of symptoms and tender points.
        Arthritis Rheum. 1983; 26: 817-825
        • Hyyppa M.T.
        • Kronhom E.
        Nocturnal motor activity in fibromyalgia patients with poor sleep quality.
        J Psychosom Res. 1995; 39: 85-91
        • Modolfsky H.
        • Saskin P.
        • Lue F.A.
        Sleep and symptoms in fiborsitis syndrome after a febrile illness.
        J Rheumatol. 1988; 15: 1701-1704
        • Moldolfsky H.
        • Lue F.A.
        • Smythe H.
        Alpha EEG sleep and morning symptoms of rheumatoid arthritis.
        J Rheumatol. 1983; 10: 373-379
        • Perlis M.L.
        • Giles D.E.
        • Bootzin R.R.
        • et al.
        Alpha sleep and information processing, perception of sleep, pain, and arousability in fibromyalgia.
        Int J Neurosci. 1997; 89: 265-280
        • Moldolfsky H.
        • Lue F.A.
        The relationship of alpha delta EEG frequencies to pain and mood in “fibrositis” patients with chlorpromazine and L-tryptophan.
        Electroencephalogr Clin Neurophysiol. 1980; 50: 71-80
        • Brostrom A.
        • Stromber A.
        • Dahlsrom U.
        • et al.
        Sleep difficulties, daytime sleepiness, and health-related quality of life in patients with chronic heart failure.
        J Cardiovasc Nurs. 2004; 19: 232-242
        • Yamashiro Y.
        • Kryger M.H.
        Sleep in heart failure.
        Sleep. 1993; 16: 513-523
        • Javaheri S.
        • Parker T.J.
        • Liming J.D.
        • et al.
        Sleep apnea in 81 ambulatory male patients with stable heart failure: types and their prevalences, consequences, and presentations.
        Circulation. 1998; 97: 2154-2159
        • Resta O.
        • Panacciulli N.
        • Di Gioia G.
        • et al.
        High prevalence of previously unknown subclinical hypothyroidism in obese patients referred to a sleep clinic for sleep disordered breathing.
        Nutr Metab Cardiovasc Dis. 2004; 14: 248-253
        • Blanco Perez J.J.
        • Blanco-Ramos M.A.
        • Zamarron Sanz C.
        • et al.
        Acromegaly and sleep apnea.
        Arch Bronconeumol. 2004; 40: 355-359
        • Rosenow F.
        • Reuter S.
        • Deuss U.
        • et al.
        Sleep apnoea in treated acromegaly: relative frequency and predisposing factors.
        Clin Endocrinol. 1996; 45: 563-569
        • Bjork S.
        • Jonsson B.
        • Westphal O.
        • et al.
        Quality of life of adults with growth hormone deficiency: a controlled study.
        Acta Paediatr Scand Suppl. 1998; 356: 55-59